ReviewEvidence-based complementary and alternative medicine : eCAM2020
Cross-Talk between Gut Microbiota and the Heart: A New Target for the Herbal Medicine Treatment of Heart Failure?
Review in Evidence-based complementary and alternative medicine : eCAM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- The gut-heart axis in heart failure: from bidirectional pathophysiological mechanisms to integrative therapeutic strategies.Frontiers in microbiology · 2026Review
- Protective activity ofPharmaceutical science advances · 2025Article
- Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism.BMC complementary medicine and therapies · 2025Article
- Associations between the gut microbiome, gut microbiology and heart failure: Current understanding and future directions.American heart journal plus : cardiology research and practice · 2022Review
- Traditional Chinese Medicine Alleviates Ulcerative Colitis via Modulating Gut Microbiota.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Can manipulation of gut microbiota really be transformed into an intervention strategy for cardiovascular disease management?Folia microbiologica · 2021Review
- Gut Microbiota and Subclinical Cardiovascular Disease in Patients with Type 2 Diabetes Mellitus.Nutrients · 2021Article
- Changes of gut microbiome composition and metabolites associated with hypertensive heart failure rats.BMC microbiology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heart failure (HF) is the severe and terminal stage of various heart diseases. A growing number of studies have suggested the potential clinical significance of gut microbiota in the pathophysiology of HF. Herbal medicine (HM) plays a role in rebalancing the composition of gut microbiota and is widely used in the prevention and treatment of HF. There are many similarities between intestinal microecology and the traditional Chinese medicine (TCM) theory, such as the holistic concept and the theory of the "heart's connection with the small intestine." These similarities provide a theoretical basis for HM to prevent and treat diseases by regulating the intestinal flora and its metabolites. In this work, the cross-talk between gut microbiota and the heart is reviewed, and the relationship between TCM and gut microbiota is discussed. Based on the current literature and research, we hypothesize that the cross-talk between gut microbiota and the heart may offer a new therapeutic target for HF intervention.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.