Evidence map›Paper›PMID 32328069›Full record

ArticleFrontiers in immunology2020

Histone Deacetylase SIRT1 Mediates C5b-9-Induced Cell Cycle in Oligodendrocytes.

Alexandru Tatomir, Gautam Rao, Dallas Boodhoo, Sonia I Vlaicu, Austin Beltrand, Freidrich Anselmo, Violeta Rus, Horea Rus

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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  6. Sirt1 inhibits macrophage polarization and inflammation in gouty arthritis by inhibiting the MAPK/NF-κB/AP-1 pathway and activating the Nrf2/HO-1 pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Alexandru TatomirDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.
Gautam RaoDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.
Dallas BoodhooDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.
Sonia I VlaicuDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.
Austin BeltrandDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.
Freidrich AnselmoDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.
Violeta RusDivision of Rheumatology and Immunology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.
Horea RusDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.
University of Maryland, Baltimore · USIuliu Hațieganu University of Medicine and Pharmacy · RO

Funding

Regulation of Oligodendrocyte SurvivalR01NS042011 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI RUS, HOREA · 2002 to 2006
$1.2M
BLRD VA I01 BX001458NINDS NIH HHS R01 NS042011
6 · The paper itself

Abstract

Sublytic levels of C5b-9 increase the survival of oligodendrocytes (OLGs) and induce the cell cycle. We have previously observed that SIRT1 co-localizes with surviving OLGs in multiple sclerosis (MS) plaques, but it is not yet known whether SIRT1 is involved in OLGs survival after exposure to sublytic C5b-9. We have now investigated the role of SIRT1 in OLGs differentiation and the effect of sublytic levels of C5b-9 on SIRT1 and phosphorylated-SIRT1 (Ser27) expression. We also examined the downstream effects of SIRT1 by measuring histone H3 lysine 9 trimethylation (H3K9me3) and the expression of cyclin D1 as a marker of cell cycle activation. OLG progenitor cells (OPCs) purified from the brain of rat pups were differentiated

Indexed as

AnimalsCell CycleCell DifferentiationCells, CulturedComplement Membrane Attack ComplexMyelin SheathOligodendrogliaPhosphatidylinositol 3-KinasesProtein Kinase CRatsRats, Sprague-DawleySirtuin 1Complement Membrane Attack ComplexPhosphatidylinositol 3-KinasesProtein Kinase CSirt1 protein, ratSirtuin 1C5b-9cell cyclecyclin D1oligodendrocyteSIRT1

Identifiers

PMID32328069
PMCPMC7160252
OpenAlexW3015406638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.