Evidence map›Paper›PMID 32327909›Full record

ArticleWorld journal of gastroenterology2020

Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model.

Bruna Girardi, Maria Pricci, Floriana Giorgio, Mariano Piazzolla, Andrea Iannone, Giuseppe Losurdo, Mariabeatrice Principi, Michele Barone, Enzo Ierardi, Alfredo Di Leo

Open access · hybridAbstract read
In one paragraph

Article in World journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Chemoprevention in Inherited Colorectal Cancer Syndromes.Clinics in colon and rectal surgery · 2024
    Review
  6. Review
  7. Molecular Pathways of Carcinogenesis in Familial Adenomatous Polyposis.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Review
  10. Article
  11. Curcumin and Colorectal Cancer: From Basic to Clinical Evidences.International journal of molecular sciences · 2020
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Bruna GirardiTHD SpA, Correggio 42015, Italy.
Maria PricciTHD SpA, Correggio 42015, Italy.
Floriana GiorgioTHD SpA, Correggio 42015, Italy.
Mariano PiazzollaGastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy.
Andrea IannoneGastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy.
Giuseppe LosurdoGastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy.
Mariabeatrice PrincipiGastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy.
Michele BaroneGastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy.
Enzo IerardiGastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy.
Alfredo Di LeoGastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy. alfredo.dileo@uniba.it.
University of Bari Aldo Moro · ITTHD (Italy) · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSome substances of plant origin have been reported to exert an effect in reducing intestinal neoplasm development, especially in animal models. Adenomatous polyposis coli multiple intestinal neoplasia - Apc

aimTo assess whether an enriched nutritional formulation (silymarin, boswellic acid and curcumin) with proven

methodsForty adenomatous polyposis coli multiple intestinal neoplasia - Apc

resultsCompared to standard, enriched diet reduced the total number (203

conclusionOur results are suggestive of a chemo-preventive synergic effect of the components (silymarin, boswellic acid and curcumin) of an enriched formulation in inherited IC. This effect may be mediated by the reduction of epithelial proliferation, the increase of apoptosis and the acceleration of villous cell renewal due to dietary formulation intake.

Indexed as

Food, FortifiedAdenomatous Polyposis ColiAdenomatous Polyposis Coli ProteinAnimalsApoptosisCell ProliferationCurcuminDisease Models, AnimalHumansIntestinal MucosaMiceMice, TransgenicSilymarinTriterpenesAdenomatous Polyposis Coli Proteinadenomatous polyposis coli protein, mouseboswellic acidCurcuminSilymarinTriterpenesApcMin/+ miceBoswelliaChemopreventive dietCurcuminFamilial adenomatous polyposisIntestinal cancer

Identifiers

PMID32327909
PMCPMC7167411
OpenAlexW3017080527

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.