Evidence map›Paper›PMID 32327639›Full record

ArticleTranslational psychiatry2020

Altered anterior cingulate glutamatergic metabolism in depressed adolescents with current suicidal ideation.

Charles P Lewis, John D Port, Caren J Blacker, A Irem Sonmez, Bhedita J Seewoo, Jarrod M Leffler, Mark A Frye, Paul E Croarkin

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Autism, youth suicide, and psychedelics: A review of the 21st century evidence.Journal of the Chinese Medical Association : JCMA · 2024
    Pooled it
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  6. Review
  7. Frontiers in psychiatry · 2026
    Article
  8. Article
  9. Article
  10. Review: Suicide and its relationship to aggression and impulsivity.Cognitive, affective & behavioral neuroscience · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
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  18. Pre-treatment functional connectivity of the cingulate cortex predicts anti-suicidal effects of serial ketamine infusions.European psychiatry : the journal of the Association of European Psychiatrists · 2023
    Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Charles P LewisDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-8791-657X
John D PortDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-4237-7776
Caren J BlackerDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-3510-0696
A Irem SonmezDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Bhedita J SeewooExperimental and Regenerative Neurosciences, School of Biological Sciences, University of Western Australia, Perth, WA, Australia.
Jarrod M LefflerDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Mark A FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Paul E CroarkinDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA. croarkin.paul@mayo.edu.ORCID http://orcid.org/0000-0001-6843-6503
Mayo Clinic · USThe University of Western Australia · AUUniversity of Minnesota Medical Center · US

Funding

Glutamatergic and GABAergic Biomarkers in rTMS for Adolescent DepressionR01MH113700 · NIMH · MAYO CLINIC ROCHESTER · PI CROARKIN, PAUL E · 2017 to 2021
$2.5M
Glutamate Probes in Adolescent DepressionK23MH100266 · NIMH · MAYO CLINIC ROCHESTER · PI CROARKIN, PAUL E · 2014 to 2017
$685k
Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) 27488NIMH NIH HHS K23 MH100266NIMH NIH HHS R01 MH113700
6 · The paper itself

Abstract

The anterior cingulate cortex (ACC) is involved in emotion regulation and salience processing. Prior research has implicated ACC dysfunction in suicidal ideation (SI) and suicidal behavior. This study aimed to quantify ACC glutamatergic concentrations and to examine relationships with SI in a sample of healthy and depressed adolescents. Forty adolescents underwent clinical evaluation and proton magnetic resonance spectroscopy (

Indexed as

Gyrus CinguliSuicidal IdeationAdolescentGlutamic AcidGlutamineHumansProton Magnetic Resonance SpectroscopyGlutamic AcidGlutamine

Identifiers

PMID32327639
PMCPMC7181616
OpenAlexW3018972880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.