Evidence map›Paper›PMID 32327635›Full record

ArticleNature communications2020

Noninvasive electromagnetic source imaging of spatiotemporally distributed epileptogenic brain sources.

Abbas Sohrabpour, Zhengxiang Cai, Shuai Ye, Benjamin Brinkmann, Gregory Worrell, Bin He

Abstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Article
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  7. Mapping epileptogenic brain using a unified spatial-temporal-spectral source imaging framework.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
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  11. Deep learning-based EEG source imaging is robust under varying electrode configurations.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Non-Invasive Brain-Computer Interfaces: State of the Art and Trends.IEEE reviews in biomedical engineering · 2025
    Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abbas SohrabpourDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-5442-9177
Zhengxiang CaiDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-1998-6442
Shuai YeDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
Benjamin BrinkmannDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-2392-8608
Gregory WorrellDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Bin HeDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA. bhe1@andrew.cmu.edu.ORCID http://orcid.org/0000-0003-2944-8602

Funding

Electrophysiological Source Imaging of Partial EpilepsyR01NS096761 · NINDS · UNIVERSITY OF MINNESOTA · PI HE, BIN · 2016 to 2025
$3.6M
Electrophysiological source imaging guided transcranial focused ultrasoundRF1MH114233 · NIMH · UNIVERSITY OF MINNESOTA · PI HE, BIN · 2017 to 2017
$2.4M
Mind-body awareness training and brain-computer interfaceR01AT009263 · NCCIH · UNIVERSITY OF MINNESOTA · PI HE, BIN · 2016 to 2020
$2.0M
Spatio-temporal Dynamic Imaging of Seizure SourcesR01EB021027 · NIBIB · UNIVERSITY OF MINNESOTA · PI HE, BIN · 2016 to 2020
$1.3M
NCCIH NIH HHS R01 AT009263NIBIB NIH HHS R01 EB021027NIMH NIH HHS RF1 MH114233NINDS NIH HHS R01 NS096761
6 · The paper itself

Abstract

Brain networks are spatiotemporal phenomena that dynamically vary over time. Functional imaging approaches strive to noninvasively estimate these underlying processes. Here, we propose a novel source imaging approach that uses high-density EEG recordings to map brain networks. This approach objectively addresses the long-standing limitations of conventional source imaging techniques, namely, difficulty in objectively estimating the spatial extent, as well as the temporal evolution of underlying brain sources. We validate our approach by directly comparing source imaging results with the intracranial EEG (iEEG) findings and surgical resection outcomes in a cohort of 36 patients with focal epilepsy. To this end, we analyzed a total of 1,027 spikes and 86 seizures. We demonstrate the capability of our approach in imaging both the location and spatial extent of brain networks from noninvasive electrophysiological measurements, specifically for ictal and interictal brain networks. Our approach is a powerful tool for noninvasively investigating large-scale dynamic brain networks.

Indexed as

AlgorithmsBrainComputer SimulationElectroencephalographyElectromagnetic PhenomenaEpilepsies, PartialFunctional NeuroimagingHumansReproducibility of ResultsSignal Processing, Computer-Assisted

Identifiers

PMID32327635
PMCPMC7181775

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.