ArticleNature communications2020
Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 75 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 139 citations in OpenAlex.
- Third trimester-equivalent alcohol exposure reduces neurons in males and increases Vglut2Neuropharmacology · 2026Article
- Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations.Nature neuroscience · 2026Article
- Article
- Essential function of Nr4a2 in subicular development and social novelty.Journal of advanced research · 2026Article
- Article
- Epileptogenicity alters intrahippocampal ripple propagation.medRxiv : the preprint server for health sciences · 2026Article
- Epileptiform Discharges Drive Unique High-frequency Oscillations Within the Retrosplenial Cortex of Mice with Third Trimester Alcohol Exposure.bioRxiv : the preprint server for biology · 2026Article
- Encoding Patterned Spatial Behavior in the Subiculum.Hippocampus · 2026Review
- Anterior and posterior retrosplenial cortex form distinct visuospatial circuits in the mouse.Nature communications · 2026Article
- Hippocampo-supramammillary coupling across sleep and wake.Scientific reports · 2026Article
- Hippocampal synchrony dynamically gates cortical connectivity across brain states.Scientific reports · 2026Article
- The irreplaceable role of sleep in building long-term memories: offline integration of free cortical units and its possible implication in autism.Frontiers in human neuroscience · 2026Article
- Exercise enhances hippocampal-cortical ripple interactions in the human brain.Brain communications · 2026Article
- Subspace communication in the hippocampal-retrosplenial axis.bioRxiv : the preprint server for biology · 2026Article
- Spatiotemporal patterns differentiate hippocampal sharp-wave ripples from interictal epileptiform discharges in mice and humans.Nature communications · 2025Article
- Ripple contributions to human memory: making the spiking content count.Nature reviews. Neuroscience · 2025Review
- Article
- Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations.bioRxiv : the preprint server for biology · 2025Article
- Article
- Cell-type-specific cholinergic control of granular retrosplenial cortex with implications for angular velocity coding across brain states.Progress in neurobiology · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Bouts of high frequency activity known as sharp wave ripples (SPW-Rs) facilitate communication between the hippocampus and neocortex. However, the paths and mechanisms by which SPW-Rs broadcast their content are not well understood. Due to its anatomical positioning, the granular retrosplenial cortex (gRSC) may be a bridge for this hippocampo-cortical dialogue. Using silicon probe recordings in awake, head-fixed mice, we show the existence of SPW-R analogues in gRSC and demonstrate their coupling to hippocampal SPW-Rs. gRSC neurons reliably distinguished different subclasses of hippocampal SPW-Rs according to ensemble activity patterns in CA1. We demonstrate that this coupling is brain state-dependent, and delineate a topographically-organized anatomical pathway via VGlut2-expressing, bursty neurons in the subiculum. Optogenetic stimulation or inhibition of bursty subicular cells induced or reduced responses in superficial gRSC, respectively. These results identify a specific path and underlying mechanisms by which the hippocampus can convey neuronal content to the neocortex during SPW-Rs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.