ArticleGenetics2020
Lung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT Ligand
Open access · bronzeAbstract read
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Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Genetic susceptibility to respiratory health effects from outdoor air pollution: a structured narrative review.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Advancing therapeutic target discovery in pulmonary diseases: evolution and application of space exploration technologies.Frontiers in cell and developmental biology · 2025Review
- Article
- Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture.Nature genetics · 2023Article
- A genome-wide association study identifies distinct variants associated with pulmonary function among European and African ancestries from the UK Biobank.Communications biology · 2023Article
- Gene-environment interactions in childhood asthma revisited; expanding the interaction concept.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Review
- Lymph node-resident dendritic cells drive TScience immunology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 13 institutions in 1 country.
Angel C Y MakDepartment of Medicine, University of California, San Francisco, California 94143 angelcymak@gmail.com.ORCID 0000-0002-5372-4198
Satria Sajuthi *Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado 80206.
Jaehyun Joo *Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Shujie Xiao *Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan 48202.
Patrick M Sleiman *Center for Applied Genomics, Children's Hospital of Philadelphia, Pennsylvania, 19104.
Marquitta J White *Department of Medicine, University of California, San Francisco, California 94143.
Eunice Y LeeDepartment of Medicine, University of California, San Francisco, California 94143.
Benjamin SaefDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Donglei HuDepartment of Medicine, University of California, San Francisco, California 94143.
Hongsheng GuiCenter for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan 48202.
Kevin L KeysDepartment of Medicine, University of California, San Francisco, California 94143.ORCID 0000-0003-4886-6666
Fred LurmannSonoma Technology, Petaluma, California 94954.
Deepti JainDepartment of Biostatistics, University of Washington, Seattle, Washington 98195.
Gonçalo AbecasisCenter for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109.
Hyun Min KangCenter for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109.
Deborah A NickersonDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195.
Soren GermerNew York Genome Center, New York, 10013.
Michael C ZodyNew York Genome Center, New York, 10013.
Lara WinterkornNew York Genome Center, New York, 10013.
Catherine ReevesNew York Genome Center, New York, 10013.
Scott HuntsmanDepartment of Medicine, University of California, San Francisco, California 94143.
Celeste EngDepartment of Medicine, University of California, San Francisco, California 94143.
Sandra SalazarDepartment of Medicine, University of California, San Francisco, California 94143.
Sam S OhDepartment of Medicine, University of California, San Francisco, California 94143.ORCID 0000-0002-2815-6037
Frank D GillilandDepartment of Preventive Medicine, Division of Environmental Health, Keck School of Medicine, University of Southern California, Los Angeles, California 90033.
Zhanghua ChenDepartment of Preventive Medicine, Division of Environmental Health, Keck School of Medicine, University of Southern California, Los Angeles, California 90033.
Rajesh KumarAnn and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611.
Fernando D MartínezAsthma and Airway Disease Research Center, University of Arizona, Tucson, Arizona 85721.
Ann Chen WuPrecision Medicine Translational Research (PRoMoTeR) Center, Department of Population Medicine, Harvard Medical School and Pilgrim Health Care Institute, Boston, Massachusetts 02215.
Elad ZivDepartment of Medicine, University of California, San Francisco, California 94143.
Hakon Hakonarson *Center for Applied Genomics, Children's Hospital of Philadelphia, Pennsylvania, 19104.
Blanca E Himes *Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
L Keoki Williams *Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan 48202.
Max A Seibold *Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Esteban G BurchardDepartment of Medicine, University of California, San Francisco, California 94143.
University of California, San Francisco · USNew York Genome Center · USHenry Ford Health System · USUniversity of Pennsylvania · USUniversity of Michigan–Ann Arbor · USUniversity of Southern California · USBrotman Baty Institute · USChildren's Hospital of Philadelphia · USHarvard Pilgrim Health Care · USLurie Children's Hospital · USSonoma Technology (United States) · USUniversity of Arizona · USUniversity of Washington · US
Funding
New York Center for Collaborative Research In Common Disease Genomics: Genome Aggregation and Joint Variant Calling for CCDG Freeze2UM1HG008901 · NHGRI · NEW YORK GENOME CENTER · PI MANIATIS, THOMAS P, WIGLER, MICHAEL H · 2016 to 2020
$56.6MSOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI Xinxin Ding · 1994 to 2026
$36.7MTranslational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3MStudies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5MThe Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MSocial Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN · 2012 to 2016
$6.4MGene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4MOptimizing imputation for diverse populations in a distributed frameworkU01HG009080 · NHGRI · STANFORD UNIVERSITY · PI KENNY, EIMEAR ELIZABETH · 2016 to 2020
$5.2MNHGRI Genome Sequencing Program Coordinating CenterU24HG008956 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI BUYSKE, STEVEN G, MATISE, TARA C. · 2016 to 2020
$4.9MTranscriptomic and Pharmacogenetic Asthma Endotypes in Minority ChildrenR01HL135156 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A, ZIV, ELAD · 2017 to 2021
$4.1MPHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMAR01AI079139 · NIAID · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2009 to 2013
$3.9MNHGRI NIH HHS U01 HG009080NHGRI NIH HHS U24 HG008956NHGRI NIH HHS UM1 HG008901NHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K01 HL140218NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL118267NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL128439NHLBI NIH HHS R01 HL133433NHLBI NIH HHS R01 HL135156NHLBI NIH HHS R01 HL141845NHLBI NIH HHS R01 HL141992NIAID NIH HHS R01 AI079139NICHD NIH HHS R01 HD085993NIDDK NIH HHS R01 DK113003NIEHS NIH HHS HHSN268201600032CNIEHS NIH HHS P30 ES006694NIEHS NIH HHS P30 ES013508NIEHS NIH HHS R01 ES015794NIMHD NIH HHS P60 MD006902NIMHD NIH HHS R01 MD010443
Abstract
Baseline lung function, quantified as forced expiratory volume in the first second of exhalation (FEV
Indexed as
Air PollutionForced Expiratory VolumeGene-Environment InteractionPolymorphism, Single NucleotideQuantitative Trait LociAdolescentAsthmaBlack or African AmericanChildChromosomes, Human, Pair 12FemaleHumansLinkage DisequilibriumMaleNasal MucosaStem Cell FactorKITLG protein, humanStem Cell FactorAfrican Americanair pollutionFEV1 gene-by-environment interactionGWASGxEKITLGSCF
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.