ArticleThe Plant cell2020
Endosidin20 Targets the Cellulose Synthase Catalytic Domain to Inhibit Cellulose Biosynthesis.
Article in The Plant cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- A fungal natural product that inhibits plant cellulose biosynthesis by disrupting cellulose synthase complexes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Myosin VIII and XI isoforms interact with the Agrobacterium VirE2 protein and facilitate its transport from the plasma membrane to the perinuclear region during plant transformation.Plant communications · 2026Article
- Poa annua becomes the first weed to evolve resistance to indaziflam applied preemergence and early-postemergence.Pest management science · 2026Article
- Empirical evidence that glucan-interacting amino acid side chains within the transmembrane channel collectively facilitate cellulose synthase function.Plant molecular biology · 2025Article
- ATG8ylation of vacuolar membrane protects plants against cell wall damage.Nature plants · 2025Article
- A cellulose synthesis inhibitor affects cellulose synthase complex secretion and cortical microtubule dynamics.Plant physiology · 2024Article
- Cellulose biosynthesis inhibitor isoxaben causes nutrient-dependent and tissue-specific Arabidopsis phenotypes.Plant physiology · 2024Article
- Functional Diversification and the Plant Secondary Cell Wall.Journal of molecular evolution · 2023Review
- The core of the matter: The catalytic core of a cellulose synthase contributes to endomembrane trafficking and plasma membrane dynamics.The Plant cell · 2023Article
- Point mutations in the catalytic domain disrupt cellulose synthase (CESA6) vesicle trafficking and protein dynamics.The Plant cell · 2023Article
- Tip growth defective1 interacts with cellulose synthase A3 to regulate cellulose biosynthesis in Arabidopsis.Plant molecular biology · 2022Article
- Cell biology of primary cell wall synthesis in plants.The Plant cell · 2022Review
- Article
- With an Ear Up against the Wall: An Update on Mechanoperception inPlants (Basel, Switzerland) · 2021Review
- Updating Insights into the Catalytic Domain Properties of PlantMolecules (Basel, Switzerland) · 2021Review
- MicroRNA775 regulates intrinsic leaf size and reduces cell wall pectin levels by targeting a galactosyltransferase gene in Arabidopsis.The Plant cell · 2021Article
- Endosidin20 does not affect cellulose synthase complex transport from ER to the Golgi.Plant signaling & behavior · 2020Article
- Endosidin20: A Key to Unlock the Secrets of Cellulose Biosynthesis.The Plant cell · 2020Article
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant cellulose is synthesized by rosette-structured cellulose synthase (CESA) complexes (CSCs). Each CSC is composed of multiple subunits of CESAs representing three different isoforms. Individual CESA proteins contain conserved catalytic domains for catalyzing cellulose synthesis, other domains such as plant-conserved sequences, and class-specific regions that are thought to facilitate complex assembly and CSC trafficking. Because of the current lack of atomic-resolution structures for plant CSCs or CESAs, the molecular mechanism through which CESA catalyzes cellulose synthesis and whether its catalytic activity influences efficient CSC transport at the subcellular level remain unknown. Here, by performing chemical genetic analyses, biochemical assays, structural modeling, and molecular docking, we demonstrate that Endosidin20 (ES20) targets the catalytic site of CESA6 in Arabidopsis (
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