ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Experience-Dependent Coding of Time-Dependent Frequency Trajectories by Off Responses in Secondary Auditory Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The what, which, when, why and who of Off responses in the auditory system.The Journal of physiology · 2025Review
- Wordsworth: A generative word dataset for comparison of speech representations in humans and neural networks.Scientific data · 2025Article
- Vocal recognition of partners by female prairie voles.iScience · 2025Article
- Article
- A new function of offset response in the primate auditory cortex: marker of temporal integration.Communications biology · 2024Article
- Vocal recognition of partners by female prairie voles.bioRxiv : the preprint server for biology · 2024Article
- Article
- Distinct nonlinear spectrotemporal integration in primary and secondary auditory cortices.Scientific reports · 2023Article
- Distinct nonlinear spectrotemporal integration in primary and secondary auditory cortices.bioRxiv : the preprint server for biology · 2023Article
- Distinct topographic organization and network activity patterns of corticocollicular neurons within layer 5 auditory cortex.Frontiers in neural circuits · 2023Article
- Offset Responses in the Auditory Cortex Show Unique History Dependence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Hearing, touching, and multisensory integration during mate choice.Frontiers in neural circuits · 2022Review
- More than the end: OFF response plasticity as a mnemonic signature of a sound's behavioral salience.Frontiers in computational neuroscience · 2022Review
- Article
- Systematic analysis of goal-related movement sequences during maternal behaviour in a female mouse model for Rett syndrome.The European journal of neuroscience · 2021Article
- Article
- Parent TRAP: Discriminating Infant Cries Requires a Higher-Order Auditory Association Area in Mice.Neuron · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
Time-dependent frequency trajectories are an inherent feature of many behaviorally relevant sounds, such as species-specific vocalizations. Dynamic frequency trajectories, even in short sounds, often convey meaningful information, which may be used to differentiate sound categories. However, it is not clear what and where neural responses in the auditory cortical pathway are critical for conveying information about behaviorally relevant frequency trajectories, and how these responses change with experience. Here, we uncover tuning to subtle variations in frequency trajectories in auditory cortex of female mice. We found that auditory cortical responses could be modulated by variations in a pure tone trajectory as small as 1/24th of an octave, comparable to what has been reported in primates. In particular, late spiking after the end of a sound stimulus was more often sensitive to the sound's subtle frequency variation compared with spiking during the sound. Such "Off" responses in the adult A2, but not those in core auditory cortex, were plastic in a way that may enhance the representation of a newly acquired, behaviorally relevant sound category. We illustrate this with the maternal mouse paradigm for natural vocalization learning. By using an ethologically inspired paradigm to drive auditory responses in higher-order neurons, our results demonstrate that mouse auditory cortex can track fine frequency changes, which allows A2 Off responses in particular to better respond to pitch trajectories that distinguish behaviorally relevant, natural sound categories.
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