Evidence map›Paper›PMID 32327516›Full record

ArticleMicrobiology resource announcements2020

Genome Sequence of Human Cytomegalovirus Ig-KG-H2, a Variant of Strain KG Propagated in the Presence of Neutralizing Antibodies.

Ahmed Al Qaffas, Salvatore Camiolo, Jenna Nichols, Andrew J Davison, Amine Ourahmane, Xiaohong Cui, Mark R Schleiss, Laura Hertel, Dirk P Dittmer, Michael A McVoy

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology resource announcements, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Ahmed Al QaffasDepartment of Pediatrics, Virginia Commonwealth University, Richmond, Virginia, USA.
Salvatore CamioloMRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Jenna NicholsMRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Andrew J DavisonMRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Amine OurahmaneDepartment of Pediatrics, Virginia Commonwealth University, Richmond, Virginia, USA.
Xiaohong CuiDepartment of Pediatrics, Virginia Commonwealth University, Richmond, Virginia, USA.
Mark R SchleissCenter for Infectious Diseases and Microbiology Translational Research, Division of Pediatric Infectious Diseases, Minneapolis, Minnesota, USA.
Laura HertelDepartment of Pediatrics, School of Medicine, University of California, San Francisco, Oakland, California, USA.
Dirk P DittmerLineberger Comprehensive Cancer Center Program in Global Oncology, Department of Microbiology and Immunology, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Michael A McVoyDepartment of Pediatrics, Virginia Commonwealth University, Richmond, Virginia, USA michael.mcvoy@vcuhealth.org.
Virginia Commonwealth University · USMRC University of Glasgow Centre for Virus Research · GBUniversity of California, San Francisco · USUniversity of North Carolina at Chapel Hill · US

Funding

Vironomics and Biostatistics CoreP01CA019014 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BLOSSOM A DAMANIA, NANCY JOAN RAAB-TRAUB · 1985 to 2026
$43.8M
Preclinical development of human CMV vaccinesR01AI088750 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MCVOY, MICHAEL A · 2010 to 2014
$3.9M
Cytomegalovirus Tropisms for Oral Cells: Key to a Vaccine to Prevent Maternal InfectionR01AI128912 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERTEL, LAURA, MCVOY, MICHAEL A · 2017 to 2020
$2.0M
Optimized Vaccines Against Congenital Infection and Maternal Reinfection with CMVR01HD079918 · NICHD · UNIVERSITY OF MINNESOTA · PI SCHLEISS, MARK R. · 2015 to 2019
$1.6M
Ability of CMV Vaccines to Induce Antibodies that Block Endocytic EntryR21AI073615 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MCVOY, MICHAEL A · 2008 to 2009
$389k
Medical Research Council MC_UU_12014/3NCI NIH HHS P01 CA019014NIAID NIH HHS R01 AI088750NIAID NIH HHS R01 AI128912NIAID NIH HHS R21 AI073615NICHD NIH HHS R01 HD079918Wellcome Trust 204870/Z/16/Z
6 · The paper itself

Abstract

Human cytomegalovirus shed in infant urine was isolated and serially passaged in fibroblasts in the presence or absence of neutralizing antibodies. Comparison of the genome sequences of representative viruses Ig-KG-H2 (passed with antibody) and ϕ-KG-B5 (passed without antibody) revealed the presence of several mutations in each virus.

Identifiers

PMID32327516
PMCPMC7180270
OpenAlexW3017258521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.