Evidence map›Paper›PMID 32327491›Full record

ArticleNeurology2020

Antiepileptic drug use and mortality among community-dwelling persons with Alzheimer disease.

Tatyana Court, Piia Lavikainen, Heidi Taipale, Jari Tiihonen, Antti Tanskanen, Sirpa Hartikainen, Anna-Maija Tolppanen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. New Onset (Incidence) of Epilepsy and Seizures in Nursing Home Residents.Journal of the American Medical Directors Association · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Tatyana CourtFrom the School of Pharmacy, Faculty of Health Sciences (T.S., P.L., H.T., S.H., A.-M.T.), Kuopio Research Centre of Geriatric Care (T.S., H.T., S.H.), and Department of Forensic Psychiatry, Niuvanniemi Hospital (H.T., J.T., A.T.), University of Eastern Finland, Kuopio; Department of Clinical Neuroscience (H.T., J.T., A.T.), Karolinska Institutet; and Centre for Psychiatry Research (J.T.), Stockholm Health Care Services, Stockholm County Council, Sweden. tatyana.sarycheva@uef.fi.ORCID 0000-0002-9779-9562
Piia LavikainenFrom the School of Pharmacy, Faculty of Health Sciences (T.S., P.L., H.T., S.H., A.-M.T.), Kuopio Research Centre of Geriatric Care (T.S., H.T., S.H.), and Department of Forensic Psychiatry, Niuvanniemi Hospital (H.T., J.T., A.T.), University of Eastern Finland, Kuopio; Department of Clinical Neuroscience (H.T., J.T., A.T.), Karolinska Institutet; and Centre for Psychiatry Research (J.T.), Stockholm Health Care Services, Stockholm County Council, Sweden.
Heidi TaipaleFrom the School of Pharmacy, Faculty of Health Sciences (T.S., P.L., H.T., S.H., A.-M.T.), Kuopio Research Centre of Geriatric Care (T.S., H.T., S.H.), and Department of Forensic Psychiatry, Niuvanniemi Hospital (H.T., J.T., A.T.), University of Eastern Finland, Kuopio; Department of Clinical Neuroscience (H.T., J.T., A.T.), Karolinska Institutet; and Centre for Psychiatry Research (J.T.), Stockholm Health Care Services, Stockholm County Council, Sweden.
Jari TiihonenFrom the School of Pharmacy, Faculty of Health Sciences (T.S., P.L., H.T., S.H., A.-M.T.), Kuopio Research Centre of Geriatric Care (T.S., H.T., S.H.), and Department of Forensic Psychiatry, Niuvanniemi Hospital (H.T., J.T., A.T.), University of Eastern Finland, Kuopio; Department of Clinical Neuroscience (H.T., J.T., A.T.), Karolinska Institutet; and Centre for Psychiatry Research (J.T.), Stockholm Health Care Services, Stockholm County Council, Sweden.
Antti TanskanenFrom the School of Pharmacy, Faculty of Health Sciences (T.S., P.L., H.T., S.H., A.-M.T.), Kuopio Research Centre of Geriatric Care (T.S., H.T., S.H.), and Department of Forensic Psychiatry, Niuvanniemi Hospital (H.T., J.T., A.T.), University of Eastern Finland, Kuopio; Department of Clinical Neuroscience (H.T., J.T., A.T.), Karolinska Institutet; and Centre for Psychiatry Research (J.T.), Stockholm Health Care Services, Stockholm County Council, Sweden.
Sirpa HartikainenFrom the School of Pharmacy, Faculty of Health Sciences (T.S., P.L., H.T., S.H., A.-M.T.), Kuopio Research Centre of Geriatric Care (T.S., H.T., S.H.), and Department of Forensic Psychiatry, Niuvanniemi Hospital (H.T., J.T., A.T.), University of Eastern Finland, Kuopio; Department of Clinical Neuroscience (H.T., J.T., A.T.), Karolinska Institutet; and Centre for Psychiatry Research (J.T.), Stockholm Health Care Services, Stockholm County Council, Sweden.
Anna-Maija TolppanenFrom the School of Pharmacy, Faculty of Health Sciences (T.S., P.L., H.T., S.H., A.-M.T.), Kuopio Research Centre of Geriatric Care (T.S., H.T., S.H.), and Department of Forensic Psychiatry, Niuvanniemi Hospital (H.T., J.T., A.T.), University of Eastern Finland, Kuopio; Department of Clinical Neuroscience (H.T., J.T., A.T.), Karolinska Institutet; and Centre for Psychiatry Research (J.T.), Stockholm Health Care Services, Stockholm County Council, Sweden.
University of Medicine Tirana · AL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the risk of death in relation to incident antiepileptic drug (AED) use compared with nonuse in people with Alzheimer disease (AD) through the assessment in terms of duration of use, specific drugs, and main causes of death.

methodsThe MEDALZ (Medication Use and Alzheimer Disease) cohort study includes all Finnish persons who received a clinically verified AD diagnosis (n = 70,718) in 2005-2011. Incident AED users were identified with 1-year washout period. For each incident AED user (n = 5,638), 1 nonuser was matched according to sex, age, and time since AD diagnosis. Analyses were conducted with Cox proportional regression models and inverse probability of treatment weighting (IPTW).

resultsNearly 50% discontinued AEDs within 6 months. Compared with nonusers, AED users had an increased relative risk of death (IPTW hazard ratio [HR], 1.23; 95% confidence interval [CI], 1.12-1.36). This was mainly due to deaths from dementia (IPTW HR, 1.62; 95% CI, 1.42-1.86). There was no difference in cardiovascular and cerebrovascular deaths (IPTW HR, 0.98; 95% CI, 0.67-1.44). The overall mortality was highest during the first 90 days of AED use (IPTW HR, 2.40; 95% CI, 1.91-3.03). Among users of older AEDs, relative risk of death was greater compared to users of newer AEDs (IPTW HR, 1.79; 95% CI, 1.52-2.16).

conclusionIn older vulnerable patients with a cognitive disorder, careful consideration of AED initiation and close adverse events monitoring are needed.

Indexed as

AgedAlzheimer DiseaseAnticonvulsantsCognitionFemaleHumansIndependent LivingMaleRisk FactorsSubstance-Related DisordersAnticonvulsants

Identifiers

PMID32327491
PMCPMC7526675
OpenAlexW3018284802

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.