Evidence map›Paper›PMID 32327478›Full record

ArticleBMJ open2020

Trends in attention-deficit and hyperactivity disorder (ADHD) medications among children and young adults in Ireland: a repeated cross-sectional study from 2005 to 2015.

MaryJo Mac Avin, Mary Teeling, Kathleen E Bennett

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

MaryJo Mac AvinPharmacology and Therapeutics, TCD, Dublin, Ireland.
Mary TeelingPharmacology and Therapeutics, TCD, Dublin, Ireland.
Kathleen E BennettPopulation Health Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland kathleenebennett@rcsi.ie.ORCID 0000-0002-2861-7665
Royal College of Surgeons in Ireland · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study examined the prescribing patterns of attention-deficit hyperactivity disorder (ADHD) medications in Ireland between 2005 and 2015 in children, adolescents and young adults, and concomitant use of psychotropic medication.

designRepeated cross-sectional study.

settingCommunity setting using pharmacy claims data in Ireland.

participantsChildren and young adults aged 0-24 years. PRIMARY AND SECONDARY OUTCOMES: Authorised medications used to treat ADHD during the study period, methylphenidate, dexamfetamine, lisdexamfetamine dimesylate and atomoxetine were extracted from a national pharmacy claims database. Dispensing of concomitant psychotropic medications including antipsychotics, anxiolytics, hypnotics/sedatives and antidepressants were examined.

resultsThe number on any ADHD medication ranged from 1913 in 2005 to 4853 in 2015, and the prevalence rate per 1000 eligible population aged <25 years increased significantly over time from 5.61 (95% CI 5.36 to 5.86) in 2005 to 8.36 (95% CI 8.13 to 8.60) in 2015 (p<0.0001). Negative binomial regression showed significant changes over time for ADHD prescribing (p<0.001), with significantly higher rates across the different age groups. The rates overall were three to five times higher in males. There was a significant increase in the percentage on concomitant antidepressants from 2% in 2005 to 6% in 2015 (p<0.001).

conclusionsThere were significantly higher rates of ADHD prescribing in children/adolescents and a significant increase in the coprescribing of antidepressants. The reasons for the increase are unclear but may reflect increasing awareness and diagnosis of the condition.

Indexed as

AdolescentAdrenergic Uptake InhibitorsAnti-Anxiety AgentsAntidepressive AgentsAntipsychotic AgentsAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildChild, PreschoolCross-Sectional StudiesDextroamphetamineFemaleHumansHypnotics and SedativesInfantInfant, NewbornAdrenergic Uptake InhibitorsAnti-Anxiety AgentsAntidepressive AgentsAntipsychotic AgentsCentral Nervous System StimulantsDextroamphetamineHypnotics and SedativesLisdexamfetamine DimesylateMethylphenidatechild & adolescent psychiatrycommunity child healthepidemiology

Identifiers

PMID32327478
PMCPMC7204927
OpenAlexW3017678224

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.