Evidence map›Paper›PMID 32327222›Full record

ArticleBioorganic & medicinal chemistry letters2020

Triazoxins: Novel nucleosides with anti-Giardia activity.

Praveen K Pogula, Atasi De Chatterjee, Miguel Chi, Harrison W VanKoten, Siddhartha Das, Steven E Patterson

Open access · greenAbstract read
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Assessment of Drug Activities againstPathogens (Basel, Switzerland) · 2024
    Article
  2. Ultrastructural Alterations of the Human PathogenPathogens (Basel, Switzerland) · 2023
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Praveen K PogulaCenter for Drug Design, College of Pharmacy, Academic Health Center, University of Minnesota, Minneapolis, MN 55455, United States.
Atasi De ChatterjeeDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968-0519, United States.
Miguel ChiDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968-0519, United States.
Harrison W VanKotenCenter for Drug Design, College of Pharmacy, Academic Health Center, University of Minnesota, Minneapolis, MN 55455, United States.
Siddhartha DasDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968-0519, United States. Electronic address: sdas@utep.edu.
Steven E PattersonCenter for Drug Design, College of Pharmacy, Academic Health Center, University of Minnesota, Minneapolis, MN 55455, United States. Electronic address: patte219@umn.edu.
The University of Texas at El Paso · USUniversity of Minnesota · US

Funding

TCCG12MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI KIRKEN, ROBERT A. · 2012 to 2018
$19.4M
RISE Scholars Program at UTEPR25GM069621 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI AGUILERA, RENATO J · 2004 to 2021
$11.2M
Sphingolipid and Mechanism of Cyst Formation by GiardiaR01AI095667 · NIAID · UNIVERSITY OF TEXAS EL PASO · PI DAS, SIDDHARTHA · 2011 to 2015
$2.1M
Discovery of a novel target for giardiasisR21AI138061 · NIAID · UNIVERSITY OF MINNESOTA · PI DAS, SIDDHARTHA, PATTERSON, STEVEN E · 2018 to 2019
$433k
NIAID NIH HHS R01 AI095667NIAID NIH HHS R21 AI138061NIGMS NIH HHS R25 GM069621NIMHD NIH HHS G12 MD007592
6 · The paper itself

Abstract

Novel nucleoside analogues named "triazoxins" were synthesized. Of these, two analogues were found to be highly effective against Giardia lamblia, an intestinal parasite and a major cause of waterborne infection, worldwide. While compound 7 reduced the growth of trophozoites in culture (IC

Indexed as

Anti-Infective AgentsCatalysisDrug DesignGiardia lambliaGiardiasisHumansImidazolesMolecular StructureNucleosidesPropanolsStructure-Activity RelationshipTrophozoitesUridine2,2-dimethoxypropaneAnti-Infective AgentsimidazoleImidazolesNucleosidesPropanolsUridineAnti-giardiasisCystGiardiaPhosphonoxinTriazoxinTrophozoite

Identifiers

PMID32327222
PMCPMC11069466
OpenAlexW3015533426

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.