Observational studyCritical care (London, England)2020
The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database.
Observational study in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Non-interventional follow-up versus fluid bolus in RESPONSE to oliguria in hemodynamically stable critically ill patients: a randomized controlled pilot trial.Critical care (London, England) · 2022Trial
- Impact of the updated SOFA-2 score on sepsis diagnosis and prognosis: a retrospective multicenter cohort study.Critical care (London, England) · 2026Observational
- Impact of 24-hour urine output trajectories on intra-abdominal hypertension risk in acute pancreatitis patients: Insights from MIMIC-IV database.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2026Article
- Toward the standardization of big datasets of urine output for AKI analysis: a multicenter validation study.Scientific reports · 2025Article
- Explainable machine learning model for prediction of 28-day all-cause mortality in immunocompromised patients in the intensive care unit: a retrospective cohort study based on MIMIC-IV database.European journal of medical research · 2025Article
- Comparison of methods to normalize urine output in critically ill patients: a multicenter cohort study.Critical care (London, England) · 2024Article
- Averaged versus Persistent Reduction in Urine Output to Define Oliguria in Critically Ill Patients: An Observational Study.Clinical journal of the American Society of Nephrology : CJASN · 2024Article
- Optimization of kidney function in cardiac surgery patients with intra-abdominal hypertension: expert opinion.Perioperative medicine (London, England) · 2024Review
- Identification of an optimal threshold to define oliguria in critically ill patients: an observational study.Critical care (London, England) · 2023Observational
- External validation of a deep-learning model to predict severe acute kidney injury based on urine output changes in critically ill patients.Journal of nephrology · 2022Article
- ISCCM Guidelines for Hemodynamic Monitoring in the Critically Ill.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022Article
- Influence of the trajectory of the urine output for 24 h on the occurrence of AKI in patients with sepsis in intensive care unit.Journal of translational medicine · 2021Article
- A deep-learning model to continuously predict severe acute kidney injury based on urine output changes in critically ill patients.Journal of nephrology · 2021Article
- Association of Oliguria With Acute Kidney Injury Diagnosis, Severity Assessment, and Mortality Among Patients With Critical Illness.JAMA network open · 2021Article
- Conceptual advances and evolving terminology in acute kidney disease.Nature reviews. Nephrology · 2021Review
- Including urinary output to define AKI enhances the performance of machine learning models to predict AKI at admission.Journal of critical care · 2021Article
- COVID-19 patients in intensive care develop predominantly oliguric acute kidney injury.Acta anaesthesiologica Scandinavica · 2021Observational
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 10 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output < 0.5 ml/kg/h) in acutely ill patients and its association with the need for renal replacement therapy (RRT) and outcome.
methodsInternational observational study. All adult (> 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis.
resultsOf the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient-oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged-oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent-oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19-1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97-1.34], p = 0.103).
conclusionsOliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.