Evidence map›Paper›PMID 32326975›Full record

ArticleBMC research notes2020

Antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male Wistar rats.

Muhamudu Kalange, Miriam Nansunga, Keneth Iceland Kasozi, Josephine Kasolo, Jackline Namulema, Jovile Kasande Atusiimirwe, Emmanuel Tiyo Ayikobua, Fred Ssempijja, Edson Ireeta Munanura, Kevin Matama and 3 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Toxicology reports · 2022
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Muhamudu KalangeDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda. kalangemuhamudu@gmail.com.ORCID https://orcid.org/0000-0002-8647-0956
Miriam NansungaDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda.ORCID https://orcid.org/0000-0001-5520-6186
Keneth Iceland KasoziDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda. kicelandy@gmail.com.ORCID https://orcid.org/0000-0002-5763-7964
Josephine KasoloDepartment of Physiology, College of Health Sciences, Makerere University, Box 7062, Kampala, Uganda.ORCID https://orcid.org/0000-0001-9551-4423
Jackline NamulemaDepartment of Physiology, Faculty of Medicine, Uzima University College CUEA, Box 2502, Kisumu, Kenya.ORCID https://orcid.org/0000-0002-3600-5255
Jovile Kasande AtusiimirweDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda.ORCID https://orcid.org/0000-0002-1600-3500
Emmanuel Tiyo AyikobuaDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda.ORCID https://orcid.org/0000-0002-4743-9622
Fred SsempijjaDepartment of Anatomy, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda.ORCID https://orcid.org/0000-0003-1849-7185
Edson Ireeta MunanuraDepartment of Pharmacy, College of Health Sciences, Makerere University, Box 7062, Kampala, Uganda.ORCID https://orcid.org/0000-0002-6218-0444
Kevin MatamaDepartment of Therapeutics and Toxicology, School of Pharmacy, Kampala International University Western Campus, Box 71, Bushenyi, Uganda.ORCID https://orcid.org/0000-0002-4000-9515
Ibrahim SemuyabaDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda.ORCID https://orcid.org/0000-0003-4165-3668
Gerald ZirintundaDepartment of Animal Production, Faculty of Agriculture and Animal Sciences, Busitema University Arapai Campus, Box 203, Soroti, Uganda.ORCID https://orcid.org/0000-0003-2487-6595
Alfred Omachonu OkpanachiDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda.ORCID https://orcid.org/0000-0002-3382-0596
Kampala International University · UGBusitema University · UGMakerere University · UGUzima University College · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAntimalarials are globally used against plasmodium infections, however, information on the safety of new antimalarial combination therapies on the gastric mucosa is scarce. The aim of this study was to investigate the effects of Artesunate-Amodiaquine and Artemether-Lumefantrine on ulcer induction. Malondialdehyde (MDA), reduced glutathione (GSH) and major histological changes in male Wistar rats following ulcer induction using Indomethacin were investigated. Gastric ulcers were in four groups; Group I was administered Artesunate, group II received Artesunate-Amodiaquine, group III received Artemether-Lumefantrine, and group IV was a positive control (normal saline). Group V was the negative control consisting of healthy rats.

resultsAntimalarial combination therapies were associated with a high gastric ulcer index than a single antimalarial agent, Artesunate. In addition, levels of MDA were significantly higher in the combination of therapies while levels of GSH were lower in comparison to Artesunate and the negative control. Microscopically, antimalarial combination therapies were associated with severe inflammation and tissue damage than Artesunate in the gastric mucosa showing that antimalarial combination therapies exert their toxic effects through oxidative stress mechanisms, and this leads to cellular damage. Findings in this study demonstrate a need to revisit information on the pharmacodynamics of major circulating antimalarial agents in developing countries.

Indexed as

AmodiaquineAnimalsAntimalarialsArtemetherArtesunateDrug Therapy, CombinationGastric MucosaGlutathioneIndomethacinInflammationLumefantrineMaleMalondialdehydeOxidative StressRatsRats, WistarAmodiaquineAntimalarialsArtemetherArtesunateGlutathioneIndomethacinLumefantrineMalondialdehydeAntimalarialsGastric ulcersMalaria in developing countriesPharmacodynamics of antimalarial agents

Identifiers

PMID32326975
PMCPMC7178572
OpenAlexW3019220391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.