Evidence map›Paper›PMID 32326954›Full record

ArticleTrials2020

A randomised controlled trial of therapist-assisted online psychological therapies for posttraumatic stress disorder (STOP-PTSD): trial protocol.

Anke Ehlers, Jennifer Wild, Emma Warnock-Parkes, Nick Grey, Hannah Murray, Alice Kerr, Alexander Rozental, Esther T Beierl, Apostolos Tsiachristas, Rafael Perera-Salazar and 2 more

Open access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. The Effect of Adverse Mental Health and Resilience on Perceived Stress by Sexual Violence History.International journal of environmental research and public health · 2022
    Article
  10. Article
  11. Ten misconceptions about trauma-focused CBT for PTSD.Cognitive behaviour therapist · 2022
    Article
  12. Article
  13. Article
  14. [Advances in the application of digital cognitive behavioral therapy in adolescent mental health issue interventions].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Anke EhlersDepartment of Experimental Psychology, University of Oxford, Paradise Square, Oxford, OX1 1TW, UK. anke.ehlers@psy.ox.ac.uk.ORCID http://orcid.org/0000-0002-8742-0192
Jennifer WildDepartment of Experimental Psychology, University of Oxford, Paradise Square, Oxford, OX1 1TW, UK.
Emma Warnock-ParkesDepartment of Experimental Psychology, University of Oxford, Paradise Square, Oxford, OX1 1TW, UK.
Nick GreySussex Partnership NHS Foundation Trust, Aldrington House, 35 New Church Road, Hove, BN3 4AG, UK.
Hannah MurrayDepartment of Experimental Psychology, University of Oxford, Paradise Square, Oxford, OX1 1TW, UK.
Alice KerrDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, London, SE5 8AF, UK.
Alexander RozentalCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Norra Stationsgatan 69, 113 64, Stockholm, Sweden.
Esther T BeierlDepartment of Experimental Psychology, University of Oxford, Paradise Square, Oxford, OX1 1TW, UK.
Apostolos TsiachristasNuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK.
Rafael Perera-SalazarNuffield Department of Primary Care Health Sciences, Radcliffe Observatory Quarter, University of Oxford, Woodstock Road, Oxford, OX2 6GG, UK.
Gerhard AnderssonCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Norra Stationsgatan 69, 113 64, Stockholm, Sweden.
David M ClarkDepartment of Experimental Psychology, University of Oxford, Paradise Square, Oxford, OX1 1TW, UK.
King's College London · GBOxford Health NHS Foundation Trust · GBUniversity of Oxford · GBKarolinska Institutet · SELinköping University · SESussex Partnership NHS Foundation Trust · GB

Funding

Wellcome Trust 200796/Z/16/ZWellcome Trust 200976
6 · The paper itself

Abstract

backgroundOver the last few decades, effective psychological treatments for posttraumatic stress disorder (PTSD) have been developed, but many patients are currently unable to access these treatments. There is initial evidence that therapist-assisted internet-based psychological treatments are effective for PTSD and may help increase access, but it remains unclear which of these treatments work best and are most acceptable to patients. This randomised controlled trial will compare a trauma-focussed and a nontrauma-focussed therapist-assisted cognitive behavioural Internet treatment for PTSD: Internet-delivered cognitive therapy for PTSD (iCT-PTSD) and internet-delivered stress management therapy (iStress-PTSD). METHODS/

designThe study is a single-blind, randomised controlled trial comparing iCT-PTSD, iStress-PTSD and a 13-week wait-list condition, with an embedded process study. Assessors of treatment outcome will be blinded to trial arm. Two hundred and seventeen participants who meet DSM-5 criteria for PTSD will be randomly allocated by a computer programme to iCT-PTSD, iStress-PTSD or wait-list at a 3:3:1 ratio. The primary assessment point is at 13 weeks, and further assessments are taken at 6, 26, 39 and 65 weeks. The primary outcome measure is the severity of PTSD symptoms as measured by the PTSD Checklist for DSM-5 (PCL-5). Secondary measures of PTSD symptoms are the Clinician Administered PTSD Scale for DSM-5 (CAPS-5) and the Impact of Event Scale-Revised (IES-R). Other symptoms and well-being will be assessed with the Patient Health Questionnaire (PHQ-9), Generalised Anxiety Disorder Scale (GAD-7), WHO (Five) Well-Being Index, Work and Social Adjustment Scale (WSAS), Endicott Quality of Life Scale (QoL), and Insomnia Sleep Index (ISI). Health economics analyses will consider quality of life, productivity, health resource utilisation, employment status and state benefits, and treatment delivery costs. Process analyses will investigate candidate mediators and moderators of outcome. Patient experience will be assessed by interview and questionnaire. DISCUSSION: This study will be the first to compare the efficacy of a trauma-focussed and nontrauma-focussed therapist-assisted online cognitive behavioural treatment for people with posttraumatic stress disorder.

trial registrationISRCTN16806208. Registered prospectively on 5 January 2018.

Indexed as

Internet-Based InterventionAdolescentAdultAgedAged, 80 and overAnxietyCognitive Behavioral TherapyFemaleHealth SurveysHumansMaleMiddle AgedPsychotherapistsQuality of LifeRandomized Controlled Trials as TopicSingle-Blind MethodClinical trialCognitive behaviour therapyCognitive therapyDigital interventionInternetPosttraumatic stress disorderProtocolRandomised controlled trialStress managementTrauma-focus

Identifiers

PMID32326954
PMCPMC7181498
OpenAlexW3009805082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.