Evidence map›Paper›PMID 32326946›Full record

ArticleJournal of ovarian research2020

Associations of CXCL1 gene 5'UTR variations with ovarian cancer.

Man Guo, Chao Xu, Yan-Zhe Chen, Qi-Wen Sun, Xin-Ying Zhao, Xin Liu, Yi Yang, Yi-Yan Hu, Fei-Feng Li, Shu-Lin Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Man GuoGenomics Research Center, College of Pharmacy (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China.
Chao XuGenomics Research Center, College of Pharmacy (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China.
Yan-Zhe ChenGenomics Research Center, College of Pharmacy (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China.
Qi-Wen SunGenomics Research Center, College of Pharmacy (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China.
Xin-Ying ZhaoDepartment of Blood Dialysis, Heilongjiang Agricultural Reclamation Bureau General Hospital, Harbin, China.
Xin LiuFifth Hospital Gynecology the City of Xiamen, Xiamen, Fujian, China.
Yi YangGenomics Research Center, College of Pharmacy (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China.
Yi-Yan HuGenomics Research Center, College of Pharmacy (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China.
Fei-Feng LiGenomics Research Center, College of Pharmacy (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China. Lifeifeng@hrbmu.edu.cn.
Shu-Lin LiuGenomics Research Center, College of Pharmacy (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China. slliu@hrbmu.edu.cn.
Harbin Medical University · CNHeilongjiang Academy of Land Reclamation Sciences · CNHeilongjiang Academy of Sciences · CN

Funding

Health and Family Planning Commission of Heilongjiang province Foundation 2017-077Heilongjiang Innovation Research Foundation for College Students 201810226070National Natural Science Foundation of China NSFC81271786, 81030029, 81671980, 81871623
6 · The paper itself

Abstract

backgroundThere are about 2.4 hundred thousand new cases and 1.5 hundred thousand deaths of ovarian cancer (OC) annually in the world. Chronic inflammation is a risk factor for OC. C-X-C motif chemokine ligand 1 (CXCL1) defects may facilitate inflammation and transactivate EGFR in ovarian cancer, but the precise haplotypes associated with the potential diseases remained largely unknown. In this work, we characterized CXCL1 gene variations to elucidate their possible associations with OC.

methodsWe analyzed the CXCL1 gene for 300 OC patients with 400 healthy participants as controls. The statistical analyses and Hardy-Weinberg equilibrium tests of the patients and control populations were conducted using the SPSS software (version 19.0) and Plink (version 1.9).

resultsThe variants rs11547681, rs201090116, rs199791199, rs181868085, rs4074 and rs1814092 within or near the CXCL1 gene were characterized. The genetic heterozygosity of rs11547681 and rs4074 was very high. Statistical analysis showed that the variant rs11547681 in the gene was closely associated with the risk of OC in the Chinese Han population, although this variant was not associated with FIGO stages or pathological grades of the patients.

conclusionsRs11547681 in CXCL1 gene was associated with the risk of OC in the Chinese Han population.

Indexed as

5' Untranslated RegionsAdultAsian PeopleChemokine CXCL1FemaleGenetic Predisposition to DiseaseGenotypeHumansMiddle AgedOvarian NeoplasmsPolymorphism, Single Nucleotide5' Untranslated RegionsChemokine CXCL1CXCL1 protein, human5’UTRChemokinesChronic inflammationCXCL1Ovarian cancer

Identifiers

PMID32326946
PMCPMC7181480
OpenAlexW3018977521

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.