Evidence map›Paper›PMID 32326904›Full record

ArticleBMC genomics2020

GWAS and co-expression network combination uncovers multigenes with close linkage effects on the oleic acid content accumulation in Brassica napus.

Min Yao, Mei Guan, Zhenqian Zhang, Qiuping Zhang, Yixin Cui, Hao Chen, Wei Liu, Habib U Jan, Kai P Voss-Fels, Christian R Werner and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 5 countries.

Min YaoCollaborative Innovation Center of Grain and Oil Crops in South China, Hunan Agricultural University, Changsha, 410128, China.
Mei GuanCollaborative Innovation Center of Grain and Oil Crops in South China, Hunan Agricultural University, Changsha, 410128, China.
Zhenqian ZhangCollaborative Innovation Center of Grain and Oil Crops in South China, Hunan Agricultural University, Changsha, 410128, China.
Qiuping ZhangCollaborative Innovation Center of Grain and Oil Crops in South China, Hunan Agricultural University, Changsha, 410128, China.
Yixin CuiCollege of Horticulture and Landscape Architecture, Southwest University, Chongqing, 400715, China.
Hao ChenCollaborative Innovation Center of Grain and Oil Crops in South China, Hunan Agricultural University, Changsha, 410128, China.
Wei LiuCollaborative Innovation Center of Grain and Oil Crops in South China, Hunan Agricultural University, Changsha, 410128, China.
Habib U JanPrecision Medicine Lab, Rehman Medical Institute (RMI), Phase 5, Hayatabad, Peshawar, 25000, Pakistan.
Kai P Voss-FelsQueensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, QLD, Australia.
Christian R WernerThe Roslin Institute University of Edinburgh Easter Bush Research Centre Midlothian, Edinburgh, EH25 9RG, UK.
Xin HeCollaborative Innovation Center of Grain and Oil Crops in South China, Hunan Agricultural University, Changsha, 410128, China.
Zhongsong LiuCollaborative Innovation Center of Grain and Oil Crops in South China, Hunan Agricultural University, Changsha, 410128, China.
Chunyun GuanCollaborative Innovation Center of Grain and Oil Crops in South China, Hunan Agricultural University, Changsha, 410128, China.
Rod J SnowdonDepartment of Plant Breeding, IFZ Research Centre for Biosystems, Land Use and Nutrition, Justus Liebig University, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany.
Wei HuaCollaborative Innovation Center of Grain and Oil Crops in South China, Hunan Agricultural University, Changsha, 410128, China. huawei@oilcrops.cn.
Lunwen QianCollaborative Innovation Center of Grain and Oil Crops in South China, Hunan Agricultural University, Changsha, 410128, China. qianlunwen@163.com.
Hunan Agricultural University · CNAgriculture and Food · AUChinese Academy of Agricultural Sciences · CNHayatabad Medical Complex · PKRoslin Institute · GBSouthwest University · CNUniversity of Giessen · DE

Funding

Hunan Province Science and Technology Plan 2014FJ1000Hunan Provincial Key Research and Development Program 2016JC2024
6 · The paper itself

Abstract

backgroundStrong artificial and natural selection causes the formation of highly conserved haplotypes that harbor agronomically important genes. GWAS combination with haplotype analysis has evolved as an effective method to dissect the genetic architecture of complex traits in crop species.

resultsWe used the 60 K Brassica Infinium SNP array to perform a genome-wide analysis of haplotype blocks associated with oleic acid (C18:1) in rapeseed. Six haplotype regions were identified as significantly associated with oleic acid (C18:1) that mapped to chromosomes A02, A07, A08, C01, C02, and C03. Additionally, whole-genome sequencing of 50 rapeseed accessions revealed three genes (BnmtACP2-A02, BnABCI13-A02 and BnECI1-A02) in the A02 chromosome haplotype region and two genes (BnFAD8-C02 and BnSDP1-C02) in the C02 chromosome haplotype region that were closely linked to oleic acid content phenotypic variation. Moreover, the co-expression network analysis uncovered candidate genes from these two different haplotype regions with potential regulatory interrelationships with oleic acid content accumulation.

conclusionsOur results suggest that several candidate genes are closely linked, which provides us with an opportunity to develop functional haplotype markers for the improvement of the oleic acid content in rapeseed.

Indexed as

Gene Expression Regulation, PlantGene Regulatory NetworksBrassica napusChromosome MappingChromosomes, PlantGene Expression ProfilingGene OntologyGenes, PlantGenetic LinkageGenome-Wide Association StudyHaplotypesOleic AcidPolymorphism, Single NucleotideWhole Genome SequencingOleic AcidBrassica napusCo-expression networkGWASHaplotypeOleic acid

Identifiers

PMID32326904
PMCPMC7181522
OpenAlexW3020426932

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.