ArticleBMC neurology2020
Impaired circadian heart rate variability in Parkinson's disease: a time-domain analysis in ambulatory setting.
Article in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Cardiovascular autonomic dysfunction in Parkinson's disease: associations with disease severity and the modulatory role of dopaminergic therapy.Arquivos de neuro-psiquiatria · 2026Article
- The brain and heart-axis in neurodegeneration and cardiovascular disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Echocardiographic insights into cardiovascular autonomic dysfunction in Parkinson's disease.Journal of Parkinson's disease · 2026Article
- Association between ultra-short heart rate variability and risk of Parkinson's disease: a prospective cohort study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Sex-differences in autonomic and cardiovascular responses to multimodal therapy in Parkinson's disease: a pilot study.BMC neurology · 2025Article
- Transforming Sleep Monitoring: Review of Wearable and Remote Devices Advancing Home Polysomnography and Their Role in Predicting Neurological Disorders.Biosensors · 2025Review
- M-ECG: extracting heart signals with a novel computational analysis of magnetoencephalography data.Frontiers in neuroimaging · 2025Article
- Neuronal threshold functions: Determining symptom onset in neurological disorders.Progress in neurobiology · 2024Review
- A diagnostic model for Parkinson's disease based on circadian rhythm-related genes.Journal of translational medicine · 2024Article
- Cardiovascular Autonomic Dysfunction in Hospitalized Patients with a Bacterial Infection: A Longitudinal Observational Pilot Study in the UK.Biomedicines · 2024Article
- The Association between Parkinson's Disease and Congestive Heart Failure in Korea: A Nationwide Longitudinal Cohort Study.Journal of personalized medicine · 2023Article
- Externally validated deep learning model to identify prodromal Parkinson's disease from electrocardiogram.Scientific reports · 2023Article
- Circadian disruption and sleep disorders in neurodegeneration.Translational neurodegeneration · 2023Review
- Predictive Value of Exercise Blood Pressure Changes for Orthostatic Hypotension in Patients With Parkinson's Disease.Journal of clinical neurology (Seoul, Korea) · 2023Article
- Can exposure to heat attenuate neurodegeneration in older adults with Parkinson's disease?Frontiers in aging neuroscience · 2023Article
- Quantification Analysis of Sleep Based on Smartwatch Sensors for Parkinson's Disease.Biosensors · 2022Article
- Circadian rhythms in neurodegenerative disorders.Nature reviews. Neurology · 2022Review
- Short-term deceleration capacity of heart rate: a sensitive marker of cardiac autonomic dysfunction in idiopathic Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Impact of Equine-Assisted Interventions on Heart Rate Variability in Two Participants with 22q11.2 Deletion Syndrome: A Pilot Study.Children (Basel, Switzerland) · 2021Article
- Heart Rate Variability Analyses in Parkinson's Disease: A Systematic Review and Meta-Analysis.Brain sciences · 2021Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeart rate variability (HRV) decreases in Parkinson's disease (PD) and it can be considered a marker for cardiovascular dysautonomia. The purpose of this pilot study is to evaluate long-term time-domain analysis of HRV of PD patients and compare the results with those of matched healthy individuals.
methodsIdiopathic PD patients without comorbidity impairing HRV, and age-matched healthy individuals were recruited in a pilot study. A long-term time domain analysis of HRV using 24-h ambulatory ECG was performed.
resultsOverall, 18 PD patients fulfilling inclusion criteria completed the evaluation (mean age was 55.6 ± 8.8, disease duration: 5.0 ± 4.7). Mean SCOPA-AUT score was 10.1 ± 7.3. Patients were on Hoehn & Yahr stage 1-2 and mean Levodopa Equivalent Dose (LED) was 311 ± 239.9. Mean of the 5-min standard deviation (SD) of R-R intervals distribution (SDNN) for all 5 min segments of the entire recording (ISDNN) was significantly lower in patients compared to controls. ISDNN was significantly different between Parkinson's disease patients and healthy controls.
conclusionsIn our population characterized by mild to moderate disease severity, time-domain assessment of HRV seemed to be a potential tool to characterize cardiovascular dysautonomia. Decrease of ISDNN in PD may reflect an autonomic derangement extending all day and night long.
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