ArticleBMC cardiovascular disorders2020
Association between the tissue accumulation of advanced glycation end products and exercise capacity in cardiac rehabilitation patients.
Article in BMC cardiovascular disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Association Between Tissue Accumulation of Skin Autofluorescence, Disease, and Exercise Capacity in Older Adults.International journal of molecular sciences · 2025Article
- Relationship Between Advanced Glycation End Products Tissue Accumulation and Frailty in Patients Undergoing Cardiac Rehabilitation.Cardiology research · 2025Article
- Urinary pentosidine as a potential biomarker of muscle and physical performance in young adult men.Journal of physiological anthropology · 2024Article
- Association between Mediterranean Diet and Advanced Glycation End Products in University Students: A Cross-Sectional Study.Nutrients · 2024Article
- Association between fingertip-measured advanced glycation end products and cardiovascular events in outpatients with cardiovascular disease.Cardiovascular diabetology · 2023Article
- The Patient's Physiological Status at the Start Determines the Success of the Inpatient Cardiovascular Rehabilitation Program.Journal of clinical medicine · 2023Article
- Advanced Glycation End Products Are Associated with Diabetes Status and Physical Functions in Patients with Cardiovascular Disease.Nutrients · 2022Article
- Advanced Glycation End Product (AGE) and Soluble Receptor of AGE (sRAGE) Levels in Relation to Periodontitis Severity and as Putative 3-Year Outcome Predictors in Patients Undergoing Coronary Artery Bypass Grafting (CABG).Journal of clinical medicine · 2022Article
- Translating the advanced glycation end products (AGEs) knowledge into real-world nutrition strategies.European journal of clinical nutrition · 2022Review
- Association of Glycative Stress With Motor and Muscle Function.Frontiers in physiology · 2022Review
- Relationship between skin autofluorescence levels and clinical events in patients with heart failure undergoing cardiac rehabilitation.Cardiovascular diabetology · 2021Observational
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Authors and funding
20 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAdvanced glycation end products (AGEs) are associated with aging, diabetes mellitus (DM), and other chronic diseases. Recently, the accumulation of AGEs can be evaluated by skin autofluorescence (SAF). However, the relationship between SAF levels and exercise capacity in patients with cardiovascular disease (CVD) remains unclear. This study aimed to investigate the association between the tissue accumulation of AGEs and clinical characteristics, including exercise capacity, in patients with CVD.
methodsWe enrolled 319 consecutive CVD patients aged ≥40 years who underwent early phase II cardiac rehabilitation (CR) at our university hospital between November 2015 and September 2017. Patient background, clinical data, and the accumulation of AGEs assessed by SAF were recorded at the beginning of CR. Characteristics were compared between two patient groups divided according to the median SAF level (High SAF and Low SAF).
resultsThe High SAF group was significantly older and exhibited a higher prevalence of DM than the Low SAF group. The sex ratio did not differ between the two groups. AGE levels showed significant negative correlations with peak oxygen uptake and ventilator efficiency (both P < 0.0001). Exercise capacity was significantly lower in the high SAF group than in the low SAF group, regardless of the presence or absence of DM (P < 0.05). A multivariate logistic regression analysis showed that SAF level was an independent factor associated with reduced exercise capacity (odds ratio 2.10; 95% confidence interval 1.13-4.05; P = 0.02).
conclusionHigh levels of tissue accumulated AGEs, as assessed by SAF, were significantly and independently associated with reduced exercise capacity. These data suggest that measuring the tissue accumulation of AGEs may be useful in patients who have undergone CR, irrespective of whether they have DM.
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