Evidence map›Paper›PMID 32326642›Full record

ArticleInternational journal of molecular sciences2020

Mark4 Inhibited the Browning of White Adipose Tissue by Promoting Adipocytes Autophagy in Mice.

Kun Yang, Jiarui Cai, Miao Pan, Qian Sun, Chao Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  6. Amidation-Modified Apelin-13 Regulates PPARBioinorganic chemistry and applications · 2021
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kun YangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China.
Jiarui CaiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China.
Miao PanKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China.
Qian SunKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China.
Chao SunKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China.
Northwest A&F University · CN

Funding

Fundamental Research Funds for the Central Universities 245201971Key Sci-tech innovation team of Shaanxi province 2017KCT-24National Nature Science Foundation of China 31572365National Nature Science Foundation of China U1804106
6 · The paper itself

Abstract

Autophagy can remove excess or dysfunctional proteins and organelles to maintain cellular homeostasis. Browning of white adipose tissue increases the energy expenditure. Microtubules affinity regulated kinase 4 (Mark4) can regulate a variety of physiological processes. According to previous studies, we speculated that Mark4-autophagy-browning of white adipose tissue had certain linkages. Here, we established two autophagy models through serum starvation and rapamycin treatment and detected that the overexpression of

Indexed as

3T3 CellsAdipocytesAdipose Tissue, BrownAdipose Tissue, WhiteAMP-Activated Protein Kinase KinasesAnimalsAutophagyAutophagy-Related Protein 7Beclin-1Cells, CulturedCell SurvivalDNA-Binding ProteinsEnergy MetabolismMaleMiceMicrotubule-Associated ProteinsAMP-Activated Protein Kinase KinasesAtg7 protein, mouseAutophagy-Related Protein 7Beclin-1Becn1 protein, mouseDNA-Binding ProteinsMap1lc3b protein, mouseMARK4 protein, mouseMicrotubule-Associated Proteinsp62TCF protein, mouseProtein KinasesProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktSirolimusTOR Serine-Threonine Kinasesautophagybrowning of white adipose tissueMark4

Identifiers

PMID32326642
PMCPMC7216233
OpenAlexW3017216740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.