Evidence map›Paper›PMID 32326556›Full record

ArticleMolecules (Basel, Switzerland)2020

Development of a Rapid Mass Spectrometric Determination of AMP and Cyclic AMP for PDE3 Activity Study: Application and Computational Analysis for Evaluating the Effect of a Novel 2-oxo-1,2-dihydropyridine-3-carbonitrile Derivative as PDE-3 Inhibitor.

Ilaria Cicalini, Barbara De Filippis, Nicola Gambacorta, Antonio Di Michele, Silvia Valentinuzzi, Alessandra Ammazzalorso, Alice Della Valle, Rosa Amoroso, Orazio Nicolotti, Piero Del Boccio and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ilaria CicaliniCentre of Advanced Studies and Technologies (CAST), University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-9792-2225
Barbara De FilippisDepartment of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Nicola GambacortaDepartment of Farmacia-Scienze del Farmaco, University "A. Moro" of Bari, 70126 Bari, Italy.
Antonio Di MicheleDepartment of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Silvia ValentinuzziCentre of Advanced Studies and Technologies (CAST), University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Alessandra AmmazzalorsoDepartment of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-4369-1772
Alice Della ValleDepartment of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Rosa AmorosoDepartment of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Orazio NicolottiDepartment of Farmacia-Scienze del Farmaco, University "A. Moro" of Bari, 70126 Bari, Italy.ORCID 0000-0001-6533-5539
Piero Del BoccioCentre of Advanced Studies and Technologies (CAST), University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-1653-2194
Letizia GiampietroDepartment of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
University of Chieti-Pescara · ITUniversity of Bari Aldo Moro · IT

Funding

Università degli Studi G. d'Annunzio Chieti - Pescara FAR local grants
6 · The paper itself

Abstract

A simple, quick, easy and cheap tandem mass spectrometry (MS/MS) method for the determination of adenosine monophosphate (AMP) and cyclic adenosine monophosphate (cAMP) has been newly developed. This novel MS/MS method was applied for the evaluation of the inhibitory effect of a novel 2-oxo-1,2-dihydropyridine-3-carbonitrile derivative, also named DF492, on PDE3 enzyme activity in comparison to its parent drug milrinone. Molecule DF492, with an IC

Indexed as

Mass SpectrometryMolecular Docking SimulationMolecular Dynamics SimulationAdenosine MonophosphateBinding SitesCyclic AMPDose-Response Relationship, DrugHumansHydrogen BondingMilrinoneMolecular StructurePhosphodiesterase 3 InhibitorsProtein BindingStructure-Activity RelationshipTandem Mass SpectrometryAdenosine MonophosphateCyclic AMPMilrinonePhosphodiesterase 3 InhibitorsAMPcyclic AMPdihydropyridinedocking studiesphosphodiesterases activitytandem mass spectrometry

Identifiers

PMID32326556
PMCPMC7221589
OpenAlexW3017124504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.