Evidence map›Paper›PMID 32326339›Full record

ReviewInternational journal of molecular sciences2020

Precision Medicine in Childhood Asthma: Omic Studies of Treatment Response.

Javier Perez-Garcia, Esther Herrera-Luis, Fabian Lorenzo-Diaz, Mario González, Olaia Sardón, Jesús Villar, Maria Pino-Yanes

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Winds of change a tale of: asthma and microbiome.Frontiers in microbiology · 2023
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Javier Perez-GarciaGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Spain.ORCID 0000-0001-7813-4381
Esther Herrera-LuisGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Spain.
Fabian Lorenzo-DiazGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Spain.
Mario GonzálezInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Spain.
Olaia SardónDivision of Pediatric Respiratory Medicine, Hospital Universitario Donostia, 20014 San Sebastián, Spain.
Jesús VillarCentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0001-5687-3562
Maria Pino-YanesGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Spain.ORCID 0000-0003-0332-437X
Universidad de La Laguna · ESSt. Michael's Hospital · CAUniversity of the Basque Country · ES

Funding

Instituto de Salud Carlos III AC15/00015Instituto de Salud Carlos III AC15/00058Ministerio de Ciencia, Innovación y Universidades PRE2018-083837Ministerio de Economía, Industria y Competitividad, Gobierno de España RYC-2015-17205Ministerio de Economía, Industria y Competitividad, Gobierno de España SAF2017-83417R
6 · The paper itself

Abstract

Asthma is a heterogeneous and multifactorial respiratory disease with an important impact on childhood. Difficult-to-treat asthma is not uncommon among children, and it causes a high burden to the patient, caregivers, and society. This review aims to summarize the recent findings on pediatric asthma treatment response revealed by different omic approaches conducted in 2018-2019. A total of 13 studies were performed during this period to assess the role of genomics, epigenomics, transcriptomics, metabolomics, and the microbiome in the response to short-acting beta agonists, inhaled corticosteroids, and leukotriene receptor antagonists. These studies have identified novel associations of genetic markers, epigenetic modifications, metabolites, bacteria, and molecular mechanisms involved in asthma treatment response. This knowledge will allow us establishing molecular biomarkers that could be integrated with clinical information to improve the management of children with asthma.

Indexed as

Precision MedicineAsthmaDisease ManagementDisease SusceptibilityEpigenomicsGenomicsHumansMetabolomicsMicrobiotaPharmacogeneticsepigenomicsgenomicsICSLTRAmetabolomicsmicrobiomemultiomicsSABAtranscriptomics

Identifiers

PMID32326339
PMCPMC7215369
OpenAlexW3017816528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.