Evidence map›Paper›PMID 32326332›Full record

ReviewMolecules (Basel, Switzerland)2020

Inverse Solvent Isotope Effects in Enzyme-Catalyzed Reactions.

Patrick L Fernandez, Andrew S Murkin

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Transition-state analysis of the arginine-specific human ADP-ribosyltransferase 1.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  3. Article
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  6. Transition State Analysis of SAMHD1 from PrimaryJournal of the American Chemical Society · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Patrick L FernandezDepartment of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, USA.ORCID 0000-0002-1862-5063
Andrew S MurkinDepartment of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, USA.ORCID 0000-0002-2559-4605
University at Buffalo, State University of New York · US

Funding

National Science Foundation CHE-1808449
6 · The paper itself

Abstract

Solvent isotope effects have long been used as a mechanistic tool for determining enzyme mechanisms. Most commonly, macroscopic rate constants such as

Indexed as

Adenosine TriphosphateAlgorithmsCatalysisCysteineEnzymesHydrogen BondingHydrogen-Ion ConcentrationIsotopesModels, TheoreticalSolventsSulfhydryl CompoundsViscosityAdenosine TriphosphateCysteineEnzymesIsotopesSolventsSulfhydryl Compoundsequilibrium isotope effectsfractionation factorinverse isotope effectskinetic isotope effectssolvent isotope effects

Identifiers

PMID32326332
PMCPMC7221790
OpenAlexW3018854680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.