Evidence map›Paper›PMID 32326145›Full record

ArticleInternational journal of molecular sciences2020

3-Hydroxybutyrate Is Active Compound in Flax That Upregulates Genes Involved in DNA Methylation.

Justyna Mierziak, Wioleta Wojtasik, Anna Kulma, Mariusz Dziadas, Kamil Kostyn, Lucyna Dymińska, Jerzy Hanuza, Magdalena Żuk, Jan Szopa

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Ketogenic diet, cardiometabolic diseases and aging.Journal of geriatric cardiology : JGC · 2026
    Article
  3. Article
  4. Article
  5. Blood and Brain Metabolites after Cerebral Ischemia.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Review
  8. Biostimulant Effects ofFrontiers in plant science · 2022
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Justyna MierziakDepartment of Genetic Biochemistry, Faculty of Biotechnology, Wroclaw University, Przybyszewskiego 63, 51-148 Wroclaw, Poland.
Wioleta WojtasikDepartment of Genetic Biochemistry, Faculty of Biotechnology, Wroclaw University, Przybyszewskiego 63, 51-148 Wroclaw, Poland.
Anna KulmaDepartment of Genetic Biochemistry, Faculty of Biotechnology, Wroclaw University, Przybyszewskiego 63, 51-148 Wroclaw, Poland.ORCID 0000-0002-5073-901X
Mariusz DziadasFaculty of Chemistry, University of Wroclaw, 50-353 Wroclaw, Poland.
Kamil KostynDepartment of Genetics, Plant Breeding and Seed Production, Faculty of Life Sciences and Technology, Wroclaw University of Environmental and Plant Sciences, Plac Grunwaldzki 24A, 53-363 Wroclaw, Poland.
Lucyna DymińskaDepartment of Bioorganic Chemistry, Wroclaw University of Economics and Business, Komandorska 118/120, 53-345 Wroclaw, Poland.
Jerzy HanuzaInstitute of Low Temperature and Structure Research, Polish Academy of Sciences, P.O. Box 1410, 50-950 Wroclaw, Poland.
Magdalena ŻukDepartment of Genetic Biochemistry, Faculty of Biotechnology, Wroclaw University, Przybyszewskiego 63, 51-148 Wroclaw, Poland.ORCID 0000-0003-3343-9303
Jan SzopaDepartment of Genetic Biochemistry, Faculty of Biotechnology, Wroclaw University, Przybyszewskiego 63, 51-148 Wroclaw, Poland.ORCID 0000-0003-0621-597X
University of Wrocław · PLPolish Academy of Sciences · PLWroclaw University of Economics and Business · PLWrocław University of Environmental and Life Sciences · PL

Funding

Narodowe Centrum Nauki 2017/27/N/NZ9/00387
6 · The paper itself

Abstract

In mammalian cells, 3-hydroxybutyrate (3-HB) is not only an intermediate metabolite during the oxidation of fatty acids, but also an important signaling molecule. On the other hand, the information about the metabolism or function of this compound in plants is scarce. In our study, we show for the first time that this compound naturally occurs in flax. The expression of bacterial

Indexed as

DNA MethylationGene Expression Regulation, Plant3-Hydroxybutyric AcidEpigenesis, GeneticFlaxGas Chromatography-Mass SpectrometryGenes, PlantMetabolic Networks and PathwaysPlants, Genetically ModifiedPropanolsRNA, MessengerSpectroscopy, Fourier Transform Infrared1-phenylpropanol3-Hydroxybutyric AcidPropanolsRNA, Messenger3-hydroxybutyrateDNA methylationflaxlignin metabolismmethyltransferase 3β-ketothiolase

Identifiers

PMID32326145
PMCPMC7215830
OpenAlexW3019701246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.