Evidence map›Paper›PMID 32326096›Full record

ArticleInternational journal of molecular sciences2020

C5-Substituted 2-Selenouridines Ensure Efficient Base Pairing with Guanosine; Consequences for Reading the NNG-3' Synonymous mRNA Codons.

Grazyna Leszczynska, Marek Cypryk, Bartlomiej Gostynski, Klaudia Sadowska, Paulina Herman, Grzegorz Bujacz, Elzbieta Lodyga-Chruscinska, Elzbieta Sochacka, Barbara Nawrot

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Mechanistic Insights Into the Oxidative Reactivity of 2-Selenouridine in tRNA.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Crystallographic analysis of the Escherichia coli tRNA seleno-modification enzyme in complex with tRNA.Acta crystallographica. Section F, Structural biology communications · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Cells · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Grazyna LeszczynskaInstitute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
Marek CyprykCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz; Poland.ORCID 0000-0003-2799-1767
Bartlomiej GostynskiCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz; Poland.
Klaudia SadowskaInstitute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
Paulina HermanInstitute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
Grzegorz BujaczInstitute of Molecular and Industrial Biotechnology, Lodz University of Technology, 4/10 Stefanowskiego St., 90-924 Lodz, Poland.ORCID 0000-0002-3787-7522
Elzbieta Lodyga-ChruscinskaInstitute of General Food Chemistry, Lodz University of Technology, 4/10 Stefanowskiego St., 90-924 Lodz, Poland.ORCID 0000-0003-3123-2413
Elzbieta SochackaInstitute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.ORCID 0000-0003-3240-1143
Barbara NawrotCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz; Poland.ORCID 0000-0002-4084-4334
Lodz University of Technology · PLCentrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk · PL

Funding

Narodowe Centrum Nauki UMO-2014/13/B/ST5/03979Narodowe Centrum Nauki UMO-2018/29/B/ST5/02509
6 · The paper itself

Abstract

5-Substituted 2-selenouridines (R5Se2U) are post-transcriptional modifications present in the first anticodon position of transfer RNA. Their functional role in the regulation of gene expression is elusive. Here, we present efficient syntheses of 5-methylaminomethyl-2-selenouridine (

Indexed as

Base PairingCodonChemical PhenomenaGuanosineModels, MolecularMolecular ConformationMolecular StructureOrganoselenium CompoundsRNA, MessengerSolutionsStatic ElectricityUridine5-((methylamino)methyl)-2-selenouridineCodonGuanosineOrganoselenium CompoundsRNA, MessengerSolutionsUridineanticodondecodingmodified uridinenew wobble base pairseleniumseleno-uridinesynonymous codonstranslation regulationtRNAwobble modification

Identifiers

PMID32326096
PMCPMC7216251
OpenAlexW3016909595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.