ArticleAnimals : an open access journal from MDPI2020
Use of Probiotics in Intravaginal Sponges in Sheep: A Pilot Study.
Article in Animals : an open access journal from MDPI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Control of Estrus in Sheep: Protocol Architectures, Seasonal Effects, and Breed-Specific Reproductive Performance.Animals : an open access journal from MDPI · 2026Review
- Addition of lactic acid bacteria to diluted ram semen as vehicle for vaginal inoculation: interaction with seminal microbiota, sperm quality and antibacterial in vitro effect against Mycoplasma agalactiae.BMC veterinary research · 2026Article
- Effect of intravaginal probiotics and enrofloxacin on vaginal microbiota, pH, vaginitis, and fertility in black Iraqi goats synchronized with progesterone impregnated sponges.Open veterinary journal · 2026Article
- Clinical evaluation of a novel intravaginal probiotic product on uterine health in postpartum dairy cows.Frontiers in veterinary science · 2026Article
- Hormone guided estrus synchronization using progesterone sponge and PMSG in goats: a cost-effective optimization strategy.Frontiers in veterinary science · 2026Article
- Comparative Effects of Intravaginal Progesterone Sponge Durations (Short vs. Long Duration) With or Without Probiotics on Vaginal Microbiota Balance and Reproductive Performance in Black Iraqi Goats.Veterinary medicine international · 2026Article
- Off-Season Reproductive Performance of Tsurcana Ewes Under Five Estrous Induction Protocols with Different Hormonal Profiles.Biology · 2025Article
- Metabarcoding analysis of the microbiota in flocks naturally infected byOne health (Amsterdam, Netherlands) · 2025Article
- Isolation of lactic acid bacteria from the reproductive tract of mares as potentially beneficial strains to prevent equine endometritis.Veterinary research communications · 2024Article
- In Vitro Interaction betweenMicroorganisms · 2024Article
- Dynamic principles of the microbiome and the bovine vagina: a review.Frontiers in microbiology · 2024Review
- Temporal changes in ewe vaginal microbiota throughout gestation.Frontiers in microbiology · 2024Article
- Impact of oestrus synchronization devices on ewes vaginal microbiota and artificial insemination outcome.Frontiers in microbiology · 2023Article
- Antibacterial potential of commercial and wild lactic acid bacteria strains isolated from ovine and caprine raw milk againstFrontiers in veterinary science · 2023Article
- Description of the vaginal microbiota in nulliparous ewes during natural mating and pregnancy: preliminary signs of the male preputial microbiota modulation.Frontiers in microbiology · 2023Article
- Characterizing the vaginal microbiota of high and low producing Poll Merino and White Suffolk ewes.Translational animal science · 2022Article
- The Use of Probiotics for Management and Improvement of Reproductive Eubiosis and Function.Nutrients · 2022Review
- Comparison of Five Protocols of Estrous Synchronization on Reproductive Performance of Hu Sheep.Frontiers in veterinary science · 2022Article
- Vaginal Microbiota Is Stable throughout the Estrous Cycle in Arabian Maress.Animals : an open access journal from MDPI · 2020Article
- The addition of Lactobacillus spp. negatively affects Mycoplasma bovis viability in bovine cervical mucus.BMC veterinary research · 2020Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Sheep estrous synchronization is mainly based on progestagen-impregnated sponges which could cause vaginitis. Several species of Lactobacillus used as probiotics are commonly used in the treatment or prevention of urogenital infections in humans. However, no studies have been performed to analyze the potential use of probiotics to prevent urogenital infections in sheep. A randomized controlled clinical trial was conducted with 21 one-year-old ewes to develop a model of probiotic infusion in vaginal sponges in order to study their influence in ewe's vaginal microbiota, general health status, fertility and prolificity. Synchronization of estrus was based on intravaginal sponges for 14 days. Bacterial communities (Enterobacteriaceae and lactic acid bacteria) were highly fluctuating over time and between animals. The safety of probiotic infusion (mix of Lactobacillus spp. 60% L. crispatus, 20% L. brevis and 20% L. gasseri) in the vagina of healthy ewes was firstly confirmed. Neutrophils were observed in 80% (8/10) of the control ewes compared to 36% (4/11) of the ewes in the probiotic group 2 days after sponge removal (p = 0.056). Fertility in the control and probiotic groups was 60% (6/10) and 91% (10/11), respectively p = 0.097. These results suggest that Lactobacillus spp. infusion in the ewe's vagina does not affect general health status or fertility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.