Evidence map›Paper›PMID 32325906›Full record

ArticleAnimals : an open access journal from MDPI2020

Nutrigenomic Effects of Long-Term Grape Pomace Supplementation in Dairy Cows.

Marianna Pauletto, Ramy Elgendy, Andrea Ianni, Elettra Marone, Mery Giantin, Lisa Grotta, Solange Ramazzotti, Francesca Bennato, Mauro Dacasto, Giuseppe Martino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  18. Antioxidant Activity of Milk and Dairy Products.Animals : an open access journal from MDPI · 2022
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marianna PaulettoDepartment of Comparative Biomedicine and Food Science, University of Padua, Viale dell'Università 16, 35020 Legnaro (PD), Italy.
Ramy ElgendyDepartment of Comparative Biomedicine and Food Science, University of Padua, Viale dell'Università 16, 35020 Legnaro (PD), Italy.
Andrea IanniFaculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo (TE), Italy.
Elettra MaroneFaculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo (TE), Italy.
Mery GiantinDepartment of Comparative Biomedicine and Food Science, University of Padua, Viale dell'Università 16, 35020 Legnaro (PD), Italy.ORCID 0000-0003-0015-3800
Lisa GrottaFaculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo (TE), Italy.
Solange RamazzottiFaculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo (TE), Italy.
Francesca BennatoFaculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo (TE), Italy.
Mauro DacastoDepartment of Comparative Biomedicine and Food Science, University of Padua, Viale dell'Università 16, 35020 Legnaro (PD), Italy.
Giuseppe MartinoFaculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo (TE), Italy.

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca CTN01_00230_413096Regione del Veneto 10065201
6 · The paper itself

Abstract

The increasing demand for more animal products put pressure on improving livestock production efficiency and sustainability. In this context, advanced animal nutrition studies appear indispensable. Here, the effect of grape pomace (GP), the polyphenol-rich agricultural by-product, was evaluated on Holstein-Friesian cows' whole-blood transcriptome, milk production and composition. Two experimental groups were set up. The first one received a basal diet and served as a control, while the second one received a 7.5% GP-supplemented diet for a total of 60 days. Milk production and composition were not different between the group; however, the transcriptome analysis revealed a total of 40 genes significantly affected by GP supplementation. Among the most interesting down-regulated genes, we found the DnaJ heat-shock protein family member A1 (DNAJA1), the mitochondrial fission factor (MFF), and the impact RWD domain protein (IMPACT) genes. The gene set enrichment analysis evidenced the positive enrichment of 'interferon alpha (IFN-α) and IFN-γ response', 'IL6-JAK-STAT3 signaling' and 'complement' genes. Moreover, the functional analysis denoted positive enrichment of the 'response to protozoan' and 'negative regulation of viral genome replication' biological processes. Our data provide an overall view of the blood transcriptomic signature after a 60-day GP supplementation in dairy cows which mainly reflects a GP-induced immunomodulatory effect.

Indexed as

dairy cowsgrape pomacenutrigenomicspolyphenolsRNA-sequencing

Identifiers

PMID32325906
PMCPMC7222749

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.