Evidence map›Paper›PMID 32325823›Full record

ArticleMolecules (Basel, Switzerland)2020

Synthesis, Docking, and In Vitro Anticoagulant Activity Assay of Hybrid Derivatives of Pyrrolo[3,2,1-

Nadezhda Novichikhina, Ivan Ilin, Anna Tashchilova, Alexey Sulimov, Danil Kutov, Irina Ledenyova, Mikhail Krysin, Khidmet Shikhaliev, Anna Gantseva, Ekaterina Gantseva and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. New Hybrid Tetrahydropyrrolo[3,2,1-Molecules (Basel, Switzerland) · 2023
    Article
  6. Frontiers in pharmacology · 2023
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Nadezhda NovichikhinaDepartment of Organic Chemistry, Faculty of Chemistry, Voronezh State University, 1 Universitetskaya sq., 394018 Voronezh, Russia.
Ivan IlinResearch Computing Center, Lomonosov Moscow State University, 119992 Moscow, Russia.
Anna TashchilovaResearch Computing Center, Lomonosov Moscow State University, 119992 Moscow, Russia.
Alexey SulimovResearch Computing Center, Lomonosov Moscow State University, 119992 Moscow, Russia.ORCID 0000-0002-8767-642X
Danil KutovResearch Computing Center, Lomonosov Moscow State University, 119992 Moscow, Russia.
Irina LedenyovaDepartment of Organic Chemistry, Faculty of Chemistry, Voronezh State University, 1 Universitetskaya sq., 394018 Voronezh, Russia.
Mikhail KrysinDepartment of Organic Chemistry, Faculty of Chemistry, Voronezh State University, 1 Universitetskaya sq., 394018 Voronezh, Russia.ORCID 0000-0002-4336-8935
Khidmet ShikhalievDepartment of Organic Chemistry, Faculty of Chemistry, Voronezh State University, 1 Universitetskaya sq., 394018 Voronezh, Russia.
Anna GantsevaFaculty of Physics, Lomonosov Moscow State University, 119992 Moscow, Russia.
Ekaterina GantsevaFaculty of Physics, Lomonosov Moscow State University, 119992 Moscow, Russia.
Nadezhda PodoplelovaRussian Children's Clinical Hospital of the Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation, 119571 Moscow, Russia.
Vladimir SulimovResearch Computing Center, Lomonosov Moscow State University, 119992 Moscow, Russia.
Lomonosov Moscow State University · RUVoronezh State University · RUPirogov Russian National Research Medical University · RU

Funding

Russian Science Foundation No 18-74-10097
6 · The paper itself

Abstract

Coagulation factor Xa and factor XIa are proven to be convenient and crucial protein targets for treatment for thrombotic disorders and thereby their inhibitors can serve as effective anticoagulant drugs. In the present work, we focused on the structure-activity relationships of derivatives of pyrrolo[3,2,1-

Indexed as

AnticoagulantsDrug DesignFactor XaFactor Xa InhibitorsFactor XIaHydrogen BondingInhibitory Concentration 50Molecular Docking SimulationPyrrolesQuinolinesStructure-Activity RelationshipAnticoagulantsFactor XaFactor Xa InhibitorsFactor XIaPyrrolespyrroloquinolineQuinolinesanticoagulantsfactor Xafactor XIamolecular dockingpyrroloquinolinones

Identifiers

PMID32325823
PMCPMC7222003
OpenAlexW3017019784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.