Evidence map›Paper›PMID 32325818›Full record

ArticleCells2020

Initiation of X Chromosome Inactivation during Bovine Embryo Development.

Bo Yu, Helena T A van Tol, Tom A E Stout, Bernard A J Roelen

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

  1. In vitro production significantly reduces metabolic differences among bovine embryos.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  2. Review
  3. Article
  4. Compensation of gene dosage on the mammalian X.Development (Cambridge, England) · 2024
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Establishment of bovine expanded potential stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  11. Review
  12. Article
  13. Article
  14. Biological Function of Long Non-coding RNA (LncRNA) Xist.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bo YuFarm Animal Health, Department of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584CM Utrecht, The Netherlands.
Helena T A van TolFarm Animal Health, Department of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584CM Utrecht, The Netherlands.
Tom A E StoutEquine Sciences, Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584CM Utrecht, The Netherlands.ORCID 0000-0001-5321-8095
Bernard A J RoelenEmbryology, Anatomy and Physiology, Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584CT Utrecht, The Netherlands.ORCID 0000-0001-9512-4708
Utrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

X-chromosome inactivation (XCI) is a developmental process that aims to equalize the dosage of X-linked gene products between XY males and XX females in eutherian mammals. In female mouse embryos, paternal XCI is initiated at the 4-cell stage; however, the X chromosome is reactivated in the inner cell mass cells of blastocysts, and random XCI is subsequently initiated in epiblast cells. However, recent findings show that the patterns of XCI are not conserved among mammals. In this study, we used quantitative RT-PCR and RNA in situ hybridization combined with immunofluorescence to investigate the pattern of XCI during bovine embryo development. Expression of

Indexed as

AnimalsBlastocystCattleDNA MethylationEmbryonic DevelopmentGene Expression Regulation, DevelopmentalGenomic ImprintingHistonesHumansRNA, Long NoncodingX Chromosome InactivationHistonesRNA, Long NoncodingbovineembryoH3K27me3inner cell massXCIXIST

Identifiers

PMID32325818
PMCPMC7226380
OpenAlexW3017238049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.