Evidence map›Paper›PMID 32325785›Full record

ArticleInternational journal of molecular sciences2020

Expression of Matrix Metalloproteinases and Their Inhibitors in Endometrium: High Levels in Endometriotic Lesions.

Alice Luddi, Camilla Marrocco, Laura Governini, Bianca Semplici, Valentina Pavone, Stefano Luisi, Felice Petraglia, Paola Piomboni

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 51 citations in OpenAlex.

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  15. Expression of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alice LuddiDepartment of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy.
Camilla MarroccoDepartment of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy.
Laura GoverniniDepartment of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy.
Bianca SempliciDepartment of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy.
Valentina PavoneDepartment of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy.
Stefano LuisiDepartment of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy.
Felice PetragliaDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy.
Paola PiomboniDepartment of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy.ORCID 0000-0003-2987-7028
University of Siena · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometriosis is a condition defined as presence of endometrium outside of the uterine cavity. These endometrial cells are able to attach and invade the peritoneum or ovary, thus forming respectively the deep infiltrating endometriosis (DIE) and the ovarian endometrioma (OMA), the ectopic lesions feature of this pathology. Endometriotic cells display high invasiveness and share some features of malignancy with cancer cells. Indeed, the tissue remodeling underlining lesion formation is achieved by matrix metalloproteinases (MMPs) and their inhibitors. Therefore, these molecules are believed to play a key role in development and pathogenesis of endometriosis. This study investigated the molecular profile of metalloproteinases and their inhibitors in healthy (

Indexed as

AdultCells, CulturedEndometriosisEndometriumEpithelial CellsFemaleFluorescent Antibody TechniqueGene Expression ProfilingHumansMatrix Metalloproteinase 10Matrix Metalloproteinase 2Matrix Metalloproteinase 3Stromal CellsTissue Inhibitor of Metalloproteinase-1Tissue Inhibitor of Metalloproteinase-2Tumor Necrosis Factor-alphaMatrix Metalloproteinase 10Matrix Metalloproteinase 2Matrix Metalloproteinase 3MMP10 protein, humanMMP2 protein, humanMMP3 protein, humanTIMP1 protein, humanTIMP2 protein, humanTissue Inhibitor of Metalloproteinase-1Tissue Inhibitor of Metalloproteinase-2TNF protein, humanTumor Necrosis Factor-alphadeep infiltrating endometriosisendometriosisendometriummetalloproteasesovarian cystsTNF

Identifiers

PMID32325785
PMCPMC7215833
OpenAlexW3017156932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.