Evidence map›Paper›PMID 32325779›Full record

ReviewInternational journal of molecular sciences2020

Force-Generating Mechanism of Axonemal Dynein in Solo and Ensemble.

Kenta Ishibashi, Hitoshi Sakakibara, Kazuhiro Oiwa

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Exome sequencing-based identification ofFrontiers in molecular biosciences · 2026
    Article
  4. Article
  5. Active fluctuations of axoneme oscillations scale with number of dynein motors.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Kenta IshibashiGraduate School of Frontier Biosciences, Osaka University, Osaka 5650871, Japan.
Hitoshi SakakibaraAdvanced ICT Research Institute, National Institute of Information and Communications Technology, Kobe 6512492, Japan.
Kazuhiro OiwaCenter for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology, Osaka 5650871, Japan.ORCID 0000-0002-1281-113X
National Institute of Information and Communications Technology · JPUbe Frontier University · JPUniversity of Hyogo · JP

Funding

Hyogo Science and Technology Association 2017Ministry of Education, Culture, Sports, Science and Technology 26440089, 17K07376, JP16H06280Takeda Science Foundation 2014
6 · The paper itself

Abstract

In eukaryotic cilia and flagella, various types of axonemal dyneins orchestrate their distinct functions to generate oscillatory bending of axonemes. The force-generating mechanism of dyneins has recently been well elucidated, mainly in cytoplasmic dyneins, thanks to progress in single-molecule measurements, X-ray crystallography, and advanced electron microscopy. These techniques have shed light on several important questions concerning what conformational changes accompany ATP hydrolysis and whether multiple motor domains are coordinated in the movements of dynein. However, due to the lack of a proper expression system for axonemal dyneins, no atomic coordinates of the entire motor domain of axonemal dynein have been reported. Therefore, a substantial amount of knowledge on the molecular architecture of axonemal dynein has been derived from electron microscopic observations on dynein arms in axonemes or on isolated axonemal dynein molecules. This review describes our current knowledge and perspectives of the force-generating mechanism of axonemal dyneins in solo and in ensemble.

Indexed as

Adenosine TriphosphateAnimalsAxonemal DyneinsAxonemeCiliaCrystallography, X-RayCytoplasmic DyneinsFlagellaMicrotubulesAdenosine TriphosphateAxonemal DyneinsCytoplasmic Dyneinsaxonemal dyneinaxonemebend formationbend propagation

Identifiers

PMID32325779
PMCPMC7215579
OpenAlexW3016864565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.