Evidence map›Paper›PMID 32325757›Full record

ArticleMolecules (Basel, Switzerland)2020

Trimeric Small Interfering RNAs and Their Cholesterol-Containing Conjugates Exhibit Improved Accumulation in Tumors, but Dramatically Reduced Silencing Activity.

Ivan V Chernikov, Daniil V Gladkikh, Ulyana A Karelina, Mariya I Meschaninova, Alya G Ven'yaminova, Valentin V Vlassov, Elena L Chernolovskaya

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Structural Modifications of siRNA Improve Its Performance In Vivo.International journal of molecular sciences · 2023
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ivan V ChernikovInstitute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk 630090, Russia.
Daniil V GladkikhInstitute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk 630090, Russia.ORCID 0000-0003-3736-0803
Ulyana A KarelinaInstitute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk 630090, Russia.
Mariya I MeschaninovaInstitute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk 630090, Russia.
Alya G Ven'yaminovaInstitute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk 630090, Russia.
Valentin V VlassovInstitute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk 630090, Russia.
Elena L ChernolovskayaInstitute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk 630090, Russia.
Institute of Chemical Biology and Fundamental Medicine · RU

Funding

Federal Agency for Scientific Organizations #АААА-А17-117020210024-8Russian Science Foundation 14-14-00697Russian Science Foundation 19-14-00251
6 · The paper itself

Abstract

Cholesterol derivatives of nuclease-resistant, anti-

Indexed as

Gene SilencingNucleic Acid ConformationAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Cell Line, TumorCholesterolGene ExpressionGenes, ReporterHumansMiceOrgan SpecificityRNA, Double-StrandedRNA, Small InterferingTissue DistributionTransfectionATP Binding Cassette Transporter, Subfamily B, Member 1CholesterolRNA, Double-StrandedRNA, Small Interfering2’-O-methyl modificationsbiodistributioncholesterol conjugatesDicer-substrate siRNAMDR1siRNATsiRNA

Identifiers

PMID32325757
PMCPMC7221888
OpenAlexW3016824473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.