Evidence map›Paper›PMID 32325423›Full record

ArticleRedox biology2020

SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion.

Ying Han, Weiju Sun, Di Ren, Jingwen Zhang, Zhibin He, Julia Fedorova, Xiaodong Sun, Fang Han, Ji Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 128 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ying HanCardiovascular Department, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, China; Department of Surgery, University of South Florida, Tampa, USA.
Weiju SunDepartment of Surgery, University of South Florida, Tampa, USA; Cardiovascular Department, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Di RenDepartment of Surgery, University of South Florida, Tampa, USA.
Jingwen ZhangDepartment of Surgery, University of South Florida, Tampa, USA.
Zhibin HeDepartment of Surgery, University of South Florida, Tampa, USA.
Julia FedorovaDepartment of Surgery, University of South Florida, Tampa, USA.
Xiaodong SunDepartment of Physiology and Biophysics, Mississippi Center for Heart Research, University of Mississippi Medical Center, Jackson, USA.
Fang HanDepartment of Physiology and Biophysics, Mississippi Center for Heart Research, University of Mississippi Medical Center, Jackson, USA.
Ji LiDepartment of Surgery, University of South Florida, Tampa, USA. Electronic address: jili@usf.edu.
University of South Florida · USJackson Memorial Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3) inflammasome was emerged as a marker of metabolic dysregulation. We revealed that age-related Sirtuin-1 (SIRT1) modulates cardiac metabolism that medicated inflammatory response during ischemia and reperfusion (I/R) stress. We hypothesize that SIRT1 attenuates NLRP3 inflammasome-dependent inflammation and pyroptosis during myocardial I/R through metabolic modulation. C57BL/6J wild type (WT) mice, inducible cardiomyocyte specific SIRT1 knockout (icSIRT1 KO) and inducible cardiomyocyte specific PDH E1α knockout (icPDH E1α KO) mice were subjected to ligation and release of left anterior descending coronary artery for in vivo regional I/R models. The echocardiography measurement demonstrated that SIRT1 agonist SRT1720 (30 μg/g) improved cardiac systolic function during 45 min of ischemia and 6 h of reperfusion in C57BL/6J WT mice. The biochemical analysis showed that I/R triggered activation of cardiac pyruvate dehydrogenase (PDH), while SIRT1 agonist SRT1720 inhibited I/R-induced PDH activity and reduced production of reactive oxygen species (ROS) during myocardial I/R. Moreover, SRT1720 regulates PDH-related glucose oxidative metabolism to reduce NLRP3 inflammasome activation and pyroptosis in an Akt signaling dependent manner during I/R. Furthermore, an impaired Akt signaling was observed in icSIRT1 KO versus SIRT1

Indexed as

InflammasomesMyocardial Reperfusion InjuryAnimalsIschemiaMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinOxidoreductasesPyruvatesReperfusionSirtuin 1InflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseOxidoreductasesPyruvatesSirt1 protein, mouseSirtuin 1Ischemia/reperfusionNLRP3 inflammasomeROSSIRT1 agonist

Identifiers

PMID32325423
PMCPMC7176991
OpenAlexW3016716247

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.