ArticleParkinsonism & related disorders2020
Rate of progression from mild cognitive impairment to dementia in an essential tremor cohort: A prospective, longitudinal study.
Article in Parkinsonism & related disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Social cognitive impact of essential tremor.Scientific reports · 2025Article
- Essential Tremor and Mortality in Older Adults: The Role of Word Recall, a Measure of Episodic Memory, in a 23-Year Follow-Up Study.Journal of clinical medicine · 2025Article
- Depressive symptoms mediate the longitudinal relationships between sleep quality and cognitive functions among older adults with mild cognitive impairment: A cross-lagged modeling analysis.Scientific reports · 2024Article
- Prevalence of and Annual Conversion Rates to Mild Cognitive Impairment and Dementia: Prospective, Longitudinal Study of an Essential Tremor Cohort.Annals of neurology · 2024Article
- Sleep problems as predictors of cognitive decline in essential tremor: A prospective longitudinal cohort study.Sleep medicine · 2024Article
- Subjective Sleep Disturbance and Lewy Pathology: Data from a Cohort of Essential Tremor Brain Donors.Neuro-degenerative diseases · 2024Article
- A nomogram for individualized prediction of mild cognitive impairment in patients with subjective cognitive decline during physical examinations: a cross-sectional study.Frontiers in aging neuroscience · 2024Article
- Baseline Depressive Symptoms as a Predictor of Incident Dementia in a Prospectively Followed Cohort of Elders with Essential Tremor.Neuro-degenerative diseases · 2024Article
- Can the Montreal Cognitive Assessment and Mini-Mental State Examination detect cognitive decline in elderly patients with essential tremor?The Clinical neuropsychologist · 2023Article
- Longitudinal study of clinical and neurophysiological features in essential tremor.European journal of neurology · 2023Article
- Displaced center of pressure on the treated side in individuals with essential tremor after radiofrequency ablation: a longitudinal case-control study.Frontiers in neurology · 2023Article
- Cognitive Performance as a Function of MAPT Haplotype: A Prospective Longitudinal Study of an Essential Tremor Cohort.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Article
- Developing a Staging Scheme for Essential Tremor: A Discussion of Organizing Principles.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Article
- Neuropsychological assessment protocol in an ongoing randomized controlled trial on posterior subthalamic area vs. ventral intermediate nucleus deep brain stimulation for essential tremor.Frontiers in neurology · 2023Article
- Differential contributions of depression, apathy, and anxiety to neuropsychological performance in Parkinson's disease versus essential tremor.Journal of clinical and experimental neuropsychology · 2022Article
- Cognitive subtypes in individuals with essential tremor seeking deep brain stimulation.The Clinical neuropsychologist · 2022Article
- Reclassification of patients with tremor syndrome and comparisons of essential tremor and essential tremor-plus patients.Journal of neurology · 2022Observational
- Brain Donation Decisions as Disease Specific Behaviors: An Elucidation of the Donation Process in the Context of Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2022Article
- Is essential tremor a degenerative disorder or an electric disorder? Degenerative disorder.International review of neurobiology · 2022Article
- Features of "ET plus" correlate with age and tremor duration: "ET plus" may be a disease stage rather than a subtype of essential tremor.Parkinsonism & related disorders · 2021Article
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7 authors.
Funding
Abstract
backgroundEssential tremor (ET), among the most common neurological diseases, is associated with cognitive dysfunction. Yet, nearly all knowledge of ET-related cognitive impairment is static and cross-sectional (e.g., prevalence), with virtually no dynamic information (i.e., course and progression, conversion rates, and clinical outcomes).
objectivesTo quantify the rate of progression from mild cognitive impairment (MCI) to dementia in a cohort of elderly ET cases.
methods167 ET cases, enrolled in a prospective, longitudinal, clinical-pathological study, underwent an extensive neuropsychological testing battery at baseline (T1), 1.5 years (T2), and 3 years (T3). Results of these assessments informed clinical diagnoses of normal cognition (ET-NC), MCI (ET-MCI), and dementia (ET-D).
resultsAt baseline, 26 cases (82.7 ± 7.7 years) were diagnosed with ET-MCI and were available for follow-up at T2. At T2, three of 26 (11.5%) had converted to ET-D. At the start of T2, 23 cases (83.6 ± 7.7 years) were diagnosed with ET-MCI and were available for follow-up at T3. At T3, six of 23 (26.1%) converted to ET-D. The average annual conversion rate from ET-MCI to ET-D was 12.5%.
conclusionsThe study of cognitive impairment in ET is a nascent field, with limited data. We show that the conversion rate from ET-MCI to ET-dementia was 12.5%. Available studies on historical controls have reported conversion rates of 2.6-6.3%. Data such as these systematically fill gaps in knowledge, creating a scientifically-derived knowledge base to guide physicians and patients in clinical settings.
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