Evidence map›Paper›PMID 32325384›Full record

ArticlePsychiatry research2020

Visual Cortical Alterations and their Association with Negative Symptoms in Antipsychotic-Naïve First Episode Psychosis.

Iniya Adhan, Paulo Lizano, Deepthi Bannai, Olivia Lutz, Kiranpreet Dhaliwal, Victor Zeng, Jean Miewald, Debra Montrose, Matcheri Keshavan

Open access · greenAbstract read
In one paragraph

Article in Psychiatry research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Iniya AdhanDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Paulo LizanoDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address: lizanopl@gmail.com.
Deepthi BannaiDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Olivia LutzDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Kiranpreet DhaliwalDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Victor ZengDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Jean MiewaldWestern Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA, USA.
Debra MontroseWestern Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA, USA.
Matcheri KeshavanDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Beth Israel Deaconess Medical Center · USHarvard University · USUniversity of Pittsburgh · US

Funding

WITHIN SUBJ VARIABILITY IN MEASUREMENTS DRUG METABOL ENZYMES IN HLTY SUBJM01RR000056 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEVINE, ARTHUR S · 1985 to 2006
$29.2M
THE ROLE OF PREFRONTAL CORTEX IN THE COGNITIVE DYSFUNCTIONS OF SCHIZOPHRENIAP50MH045156 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SAMPSON, ALLAN R · 1990 to 2007
$17.9M
Institutional Career Development CoreKL2TR002542 · NCATS · HARVARD MEDICAL SCHOOL · PI BREDELLA, MIRIAM ANTOINETTE, RUTKOVE, SEWARD B. · 2018 to 2022
$8.7M
CORTICAL PRUNING AND SCHIZOPHRENIAK02MH001180 · NIMH · WAYNE STATE UNIVERSITY · PI KESHAVAN, MATCHERI S. · 1995 to 2005
$648k
NCATS NIH HHS KL2 TR002542NCRR NIH HHS M01 RR000056NIMHD NIH HHS L32 MD014380NIMH NIH HHS K02 MH001180NIMH NIH HHS P50 MH045156
6 · The paper itself

Abstract

Visual perceptual and processing deficits are common in schizophrenia and possibly point towards visual pathway alterations. However, no studies have examined visual cortical morphology in first-episode psychosis (FEP). In an antipsychotic-naïve FEP population, we investigated primary visual (V1), association area (V2), and motion perception (V5/MT) morphology compared to controls. We found reductions in the V1 and V2 areas, greater MT area and lower MT thickness in the FEP-schizophrenia group when compared to controls. Also, lower MT thickness was associated with worse negative symptoms. Our results shed light on this poorly studied area of visual cortex morphology in FEP.

Indexed as

Antipsychotic AgentsAdolescentAdultChildFemaleHumansMaleMiddle AgedMotion PerceptionPsychotic DisordersSchizophreniaVisual CortexVisual PathwaysYoung AdultAntipsychotic AgentsFirst episode psychosisNegative symptomsVisual cortex

Identifiers

PMID32325384
PMCPMC7333935
OpenAlexW3017300156

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.