Evidence map›Paper›PMID 32325294›Full record

ArticleEnvironmental research2020

Urinary levels of environmental phenols and parabens and antioxidant enzyme activity in the blood of women.

Anna Z Pollack, Sunni L Mumford, Jenna R Krall, Andrea Carmichael, Victoria C Andriessen, Kurunthachalam Kannan, Enrique F Schisterman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Variability in urinary concentrations of primary aromatic amines.The Science of the total environment · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Anna Z PollackDepartment of Global and Community Health, College of Health and Human Services, George Mason University, Fairfax, VA, 22030, USA. Electronic address: apollac2@gmu.edu.
Sunni L MumfordEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Jenna R KrallDepartment of Global and Community Health, College of Health and Human Services, George Mason University, Fairfax, VA, 22030, USA.
Andrea CarmichaelDepartment of Global and Community Health, College of Health and Human Services, George Mason University, Fairfax, VA, 22030, USA.
Victoria C AndriessenEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Kurunthachalam KannanWadsworth Center, New York State Department of Health, Empire State Plaza, P.O. Box 509, Albany, NY, 12201-0509, United States; Department of Pediatrics, New York University School of Medicine, New York, NY, 10016, United States.
Enrique F SchistermanEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USGeorge Mason University · USWadsworth Center · US

Funding

Oxidative Stress, Hormones and Women's HealthZ01HD008762 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SCHISTERMAN, ENRIQUE F · 2003 to 2008
$264k
Intramural NIH HHS Z01 HD008762NICHD NIH HHS HHSN275201100002CNICHD NIH HHS HHSN275201100002G
6 · The paper itself

Abstract

backgroundThe balance between oxidative stress and antioxidant enzymes is one biological mechanism by which environmental and lifestyle exposures affect health outcomes. Yet, no studies have examined the relationship between environmental phenolic compounds and parabens or their mixtures in relation to antioxidant enzyme activity in women of reproductive age.

methodsSixteen environmental phenols and parabens were measured in urine 2-5 times across two months of follow-up in 143 women aged 18-44 years. Four antioxidant enzymes, erythrocyte and plasma glutathione peroxidase (eGPx, pGPx), glutathione reductase (GSHR), superoxide dismutase (SOD) were measured in plasma. Linear mixed models were adjusted for age, body mass index, race, and creatinine and were weighted with inverse probability of exposure weights. Multi-chemical exposures were estimated using hierarchical principal component analysis (PCA).

resultsIn line with our hypothesis that environmental phenols and parabens would be associated with decreased antioxidant enzymes, butyl, benzyl, ethyl, and propyl parabens were associated with lower levels of eGPx. Methyl paraben, 2,4-dichlorophenol and 2,5-dichlorophenol were associated with reduced SOD. 2,4,6-trichlorophenol was associated with increased levels of pGPx and GSHR. Several parabens were associated with modest decreases in eGPx and SOD, biomarkers of antioxidant defense. Increases in pGPx and GSHR were noted in relation to butyl and ethyl parabens. Co-exposures to parabens were associated with decreased eGPx (β = -1.08, 95% CI: -1.74, -0.43) in principal components mixed models, while co-exposure to benzophenones-3 and -1 were associated with increased eGPx (β = 0.92, 95% CI: 0.20, 1.64).

conclusionThese findings indicate that nonpersistent chemicals altered antioxidant enzyme activity. Further human studies are necessary to delineate the relationship between environmental phenol and paraben exposures with erythrocyte and plasma activities of antioxidant enzymes.

Indexed as

ParabensPhenolsAdolescentAdultAntioxidantsBiomarkersEnvironmental ExposureFemaleHumansOxidative StressYoung AdultAntioxidantsBiomarkersParabensPhenolsAntioxidant enzymeBenzophenoneGlutathione reductaseParabenPeroxidasePhenolSuperoxide dismutaseTriclosanWomen

Identifiers

PMID32325294
PMCPMC7363544
OpenAlexW3016610890

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.