ReviewAgeing research reviews2020
MRI-based biomarkers of accelerated aging and dementia risk in midlife: how close are we?
Review in Ageing research reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Morphologic and functional alterations in the parasagittal dural space in mild cognitive impairment.Scientific reports · 2025Article
- Judged by your neighbors: A novel framework for personalized assessment of brain structural aging effects in diverse populations.medRxiv : the preprint server for health sciences · 2025Article
- Advancing Alzheimer's Diagnosis with AI-Enhanced MRI: A Review of Challenges and Implications.Current neuropharmacology · 2025Review
- Preclinical Alzheimer's and vascular biomarkers alter brain aging in cognitively normal adults: a MRI-based study.Frontiers in aging neuroscience · 2025Article
- Exploring the Relationship Between CAIDE Dementia Risk and EEG Signal Activity in a Healthy Population.Brain sciences · 2024Article
- Mapping macrostructural and microstructural brain alterations in patients with neuronal intranuclear inclusion disease.Neuroradiology · 2024Article
- Association between household size and risk of incident dementia in the UK Biobank study.Scientific reports · 2024Article
- Corneal nerve loss predicts dementia in patients with mild cognitive impairment.Annals of clinical and translational neurology · 2023Article
- Turning Back the Clock: A Retrospective Single-Blind Study on Brain Age Change in Response to Nutraceuticals Supplementation vs. Lifestyle Modifications.Brain sciences · 2023Article
- Diminished Structural Brain Integrity in Long-term Cannabis Users Reflects a History of Polysubstance Use.Biological psychiatry · 2022Article
- A Neuroimaging Signature of Cognitive Aging from Whole-Brain Functional Connectivity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy.Nature aging · 2021Article
- Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study.Frontiers in aging neuroscience · 2021Article
- Advanced brain ageing in Parkinson's disease is related to disease duration and individual impairment.Brain communications · 2021Article
- Midlife Cardiovascular Fitness Is Reflected in the Brain's White Matter.Frontiers in aging neuroscience · 2021Article
- Increased Brain Age Gap Estimate (BrainAGE) in Young Adults After Premature Birth.Frontiers in aging neuroscience · 2021Article
- Globally Aging Cortical Spontaneous Activity Revealed by Multiple Metrics and Frequency Bands Using Resting-State Functional MRI.Frontiers in aging neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The global population is aging, leading to an increasing burden of age-related neurodegenerative disease. Efforts to intervene against age-related dementias in older adults have generally proven ineffective. These failures suggest that a lifetime of brain aging may be difficult to reverse once widespread deterioration has occurred. To test interventions in younger populations, biomarkers of brain aging are needed that index subtle signs of accelerated brain deterioration that are part of the putative pathway to dementia. Here I review potential MRI-based biomarkers that could connect midlife brain aging to later life dementia. I survey the literature with three questions in mind, 1) Does the biomarker index age-related changes across the lifespan? 2) Does the biomarker index cognitive ability and cognitive decline? 3) Is the biomarker sensitive to known risk factors for dementia? I find that while there is preliminary support for some midlife MRI-based biomarkers for accelerated aging, the longitudinal research that would best answer these questions is still in its infancy and needs to be further developed. I conclude with suggestions for future research.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.