ArticleThe Journal of infection2020
The profile of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus pneumonia.
Article in The Journal of infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 5 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 5 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Children's role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility.Scientific reports · 2021Pooled it
- Neurological Complications of SARS-CoV-2 Infection in Children: A Systematic Review and Meta-Analysis.Journal of tropical pediatrics · 2021Pooled it
- Routine laboratory testing to determine if a patient has COVID-19.The Cochrane database of systematic reviews · 2020Pooled it
- Clinical Features and Outcome of SARS-CoV-2 Infection in Children: A Systematic Review and Meta-analysis.Indian pediatrics · 2020Pooled it
- SARS-COV-2 infection in children and newborns: a systematic review.European journal of pediatrics · 2020Pooled it
- Risk prediction of pneumocystis jirovecii pneumonia in kidney transplant recipients using a clinical nomogram.Frontiers in cellular and infection microbiology · 2026Article
- The underlying mechanism behind the different outcomes of COVID-19 in children and adults.Frontiers in immunology · 2025Review
- SARS-CoV-2 Infections in a Triad of Primary School Learners (Grades 1-7), Their Parents, and Teachers in KwaZulu-Natal, South Africa: Protocol for a Cross-Sectional and Nested Case-Cohort Study.JMIR research protocols · 2024Article
- A preliminary prediction model of pediatric Mycoplasma pneumoniae pneumonia based on routine blood parameters by using machine learning method.BMC infectious diseases · 2024Article
- The mechanisms of milder clinical symptoms of COVID-19 in children compared to adults.Italian journal of pediatrics · 2024Review
- Pneumonia Caused byInternational medical case reports journal · 2024Article
- Review
- T Lymphocyte Subset Counts and Interferon-Gamma Production in Adults and Children with COVID-19: A Narrative Review.Journal of personalized medicine · 2023Review
- COVID-19 and liver dysfunction in children: Current views and new hypotheses.World journal of hepatology · 2023Review
- Incidence of SARS-CoV-2 Co-infections During the Second Wave in Sub-Himalayan Region, India.Cureus · 2023Article
- Molecular Determinants of the Early Life Immune Response to COVID-19 Infection and Immunization.Vaccines · 2023Review
- The Role of Immunity in the Pathogenesis of SARS-CoV-2 Infection and in the Protection Generated by COVID-19 Vaccines in Different Age Groups.Pathogens (Basel, Switzerland) · 2023Review
- Policies on children and schools during the SARS-CoV-2 pandemic in Western Europe.Frontiers in public health · 2023Review
- Factors affecting the simple febrile seizures in COVID-19 children: a case-control study from China.Frontiers in neurology · 2023Article
- Liver injury in COVID-19: Holds ferritinophagy-mediated ferroptosis accountable.World journal of clinical cases · 2022Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe study was aimed at investigating the characteristics of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus (2019-nCoV) pneumonia.
methodsChildren with 2019-nCoV pneumonia or with respiratory syncytial virus (RSV) pneumonia were included. Data including lymphocyte subsets and serum cytokines were collected and analyzed.
results56 patients were included in the study, 40 children with 2019-nCoV pneumonia and 16 children with RSV pneumonia. Compared with children with RSV pneumonia, patients with 2019-nCoV pneumonia had higher count of CD3+8+ lymphocyte, higher percentages of CD3+, CD3+8+ lymphocytes and a lower percentage of CD19+ lymphocyte. The serum IL-10 level was significantly higher in children with RSV pneumonia. One 2019-nCoV pneumonia child who was with an obvious increase of IL-10 developed severe pneumonia.
conclusionsImmune response played a very important role in the development of 2019-nCoV pneumonia. The effective CD8+ T cell response might influence the severity of 2019-nCoV pneumonia. The adaptable change in IL-10 level might contribute to the relatively mild pneumonia symptoms in children with 2019-nCoV pneumonia and bacterial co-infection might be a risk factor of severe 2019-nCoV pneumonia.
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