ArticleDevelopmental and comparative immunology2020
Rainbow trout mount a robust specific immune response upon anal administration of thymus-independent antigens.
Article in Developmental and comparative immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Protective IgM-mediated immunity againstFrontiers in immunology · 2025Article
- L-methionine supplementation modulates IgMFrontiers in immunology · 2023Article
- Review
- RNA-Seq of Single Fish Cells - Seeking Out the Leukocytes Mediating Immunity in Teleost Fishes.Frontiers in immunology · 2022Review
- Functional and Phenotypic Characterization of B Cells in the Teleost Adipose Tissue.Frontiers in immunology · 2022Article
- Teleost fish IgMFrontiers in immunology · 2022Article
- Mucosal immunoglobulins of teleost fish: A decade of advances.Developmental and comparative immunology · 2021Review
- Oral Probiotic Vaccine Expressing Koi Herpesvirus (KHV) ORF81 Protein Delivered by Chitosan-Alginate Capsules Is a Promising Strategy for Mass Oral Vaccination of Carps against KHV Infection.Journal of virology · 2021Article
- CD38 Defines a Subset of B Cells in Rainbow Trout Kidney With High IgM Secreting Capacities.Frontiers in immunology · 2021Article
- Sinomenine Hydrochloride Ameliorates Fish Foodborne EnteritisFrontiers in immunology · 2021Article
- Application of Outer Membrane Protein-Based Vaccines Against Major Bacterial Fish Pathogens in India.Frontiers in immunology · 2020Review
- Systemic and Mucosal B and T Cell Responses Upon Mucosal Vaccination of Teleost Fish.Frontiers in immunology · 2020Review
- Insights Into the Evolution of theFrontiers in immunology · 2020Article
- Immunoglobulins, Mucosal Immunity and Vaccination in Teleost Fish.Frontiers in immunology · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the strong demand for orally-delivered fish vaccines and the deficient response of those currently available in the market, little is known about how teleost B cells differentiate to antibody secreting cells (ASCs) in response to antigens delivered to the intestinal mucosa. To fill this gap, in the current study, we have studied the dynamics of B cell differentiation in spleen and kidney of rainbow trout (Oncorhynchus mykiss) anally immunized with antigens catalogued in mammals as thymus dependent (TD) or thymus-independent (TI). Our results show that, in the absence of additional adjuvants, rainbow trout preferentially responded to a model TI antigen such as TNP-LPS (2,4,6-trinitrophenyl hapten conjugated to lipopolysaccharide). The anal administration of TNP-LPS elicited TNP-specific serum antibodies, and a significant increase in the number of total and TNP-specific ASCs in both spleen and kidney, being the kidney the site where most ASCs are found at later time points. In the spleen, a proliferative response of both IgM
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