ReviewNeuron2020
Modulation of Human Memory by Deep Brain Stimulation of the Entorhinal-Hippocampal Circuitry.
Review in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Intestinal Flora Balance Therapy Based on Probiotic Support Improves Cognitive Function and Symptoms in Patients with Alzheimer's Disease: A Systematic Review and Meta-analysis.BioMed research international · 2022Pooled it
- Integrating neural decoding, memristive materials, and adaptive control frameworks for next-generation hippocampal memory prosthetics.iScience · 2026Review
- Article
- Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain-Machine Interface.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Structural and Functional Connectivity Predict the Effects of Direct Brain Stimulation on Memory.bioRxiv : the preprint server for biology · 2026Article
- Improved autobiographical memory with central thalamic deep brain stimulation in traumatic brain injury.Brain communications · 2026Article
- Hypoactivity of the prelimbic cortex projecting to the lateral entorhinal cortex contributes to neuropathic pain-induced object recognition memory impairment in mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Optimizing real-time phase detection in diverse rhythmic biological signals for phase-specific neurostimulation.Journal of neural engineering · 2025Article
- Mesoscale connectivity of the human hippocampus and fimbria revealed by ex vivo diffusion MRI.NeuroImage · 2025Article
- Exploring individual differences in amygdala-mediated memory modulation.Cognitive, affective & behavioral neuroscience · 2025Article
- Recommendations for the Safe Application of Temporal Interference Stimulation in the Human Brain Part I: Principles of Electrical Neuromodulation and Adverse Effects.Bioelectromagnetics · 2025Review
- The intersection of near-death experiences (NDEs) and traumatic brain injury (TBI): neurobiological, phenomenological, and creative implications.Frontiers in human neuroscience · 2025Article
- Computational insights into magnetoelectric nanoparticles for neural stimulation.Frontiers in neuroscience · 2025Article
- Neural interfaces: Bridging the brain to the world beyond healthcare.Exploration (Beijing, China) · 2024Article
- Why does invasive brain stimulation sometimes improve memory and sometimes impair it?PLoS biology · 2024Article
- Microglia and Astrocytes in Alzheimer's Disease: Significance and Summary of Recent Advances.Aging and disease · 2024Review
- Membrane remodeling by FAM92A1 during brain development regulates neuronal morphology, synaptic function, and cognition.Nature communications · 2024Article
- Targeting papez circuit for cognitive dysfunction- insights into deep brain stimulation for Alzheimer's disease.Heliyon · 2024Review
- Causal functional maps of brain rhythms in working memory.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Flexible, scalable, high channel count stereo-electrode for recording in the human brain.Nature communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Neurological disorders affecting human memory present a major scientific, medical, and societal challenge. Direct or indirect deep brain stimulation (DBS) of the entorhinal-hippocampal system, the brain's major memory hub, has been studied in people with epilepsy or Alzheimer's disease, intending to enhance memory performance or slow memory decline. Variability in the spatiotemporal parameters of stimulation employed to date notwithstanding, it is likely that future DBS for memory will employ closed-loop, nuanced approaches that are synergistic with native physiological processes. The potential for editing human memory-decoding, enhancing, incepting, or deleting specific memories-suggests exciting therapeutic possibilities but also raises considerable ethical concerns.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.