Evidence map›Paper›PMID 32325052›Full record

ArticleNeuron2020

Flipping the Switch: Homeostatic Tuning of Chandelier Synapses Follows Developmental Changes in GABA Polarity.

Anna M Lipkin, Kevin J Bender

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Axon Initial Segment GABA Inhibits Action Potential Generation throughout Periadolescent Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  2. Review
  3. Functional Microstructure of CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Anna M LipkinNeuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, Kavli Institute for Fundamental Neuroscience, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Kevin J BenderWeill Institute for Neurosciences, Kavli Institute for Fundamental Neuroscience, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: kevin.bender@ucsf.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Homeostatic plasticity rules are well described for glutamatergic synapses but less clear for GABAergic synapses. In this issue of Neuron, Pan-Vazquez et al. (2020) leverage the precise targeting of chandelier-to-pyramidal cell connectivity to understand how homeostatic plasticity regulates GABAergic synapses, showing that these synapses maintain homeostatic rules even as they flip from exciting to inhibiting pyramidal cells.

Indexed as

Axon Initial SegmentAxonsgamma-Aminobutyric AcidPyramidal CellsSynapsesgamma-Aminobutyric Acid

Identifiers

PMID32325052

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.