ArticleObesity (Silver Spring, Md.)2020
Does High Cardiorespiratory Fitness Confer Some Protection Against Proinflammatory Responses After Infection by SARS-CoV-2?
Article in Obesity (Silver Spring, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04957199 (Physiotherapist Awareness in the Community During the COVID-19 Pandemic Process), which is not on this map. Cited by 93 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physiotherapist Awareness in the Community During the COVID-19 Pandemic Process
Who cites it
93 citing papers in PubMed, 6 syntheses or guidelines pooled it, 189 citations in OpenAlex.
- Cardiorespiratory fitness and health in children and adolescents: an overview of systematic reviews with meta-analyses representing over 125 000 observations covering 33 health-related outcomes.British journal of sports medicine · 2025Pooled it
- Obesity as a Risk Factor for Complications and Mortality in Individuals with SARS-CoV-2: A Systematic Review.Nutrients · 2024Pooled it
- Association between physical activity and risk of COVID-19 infection or clinical outcomes of the patients with COVID-19: A systematic review and meta-analysis.Journal of preventive medicine and hygiene · 2023Pooled it
- The epidemiology, pathophysiological mechanisms, and management toward COVID-19 patients with Type 2 diabetes: A systematic review.Primary care diabetes · 2021Pooled it
- Visceral adiposity, subcutaneous adiposity, and severe coronavirus disease-2019 (COVID-19): Systematic review and meta-analysis.Clinical nutrition ESPEN · 2021Pooled it
- Body mass index and outcome in patients with COVID-19: A dose-response meta-analysis.Diabetes & metabolism · 2021Pooled it
- Prior SARS-CoV-2 infection does not increase heat stress during one hour of exercise in a hot and moderately humid environment.European journal of applied physiology · 2025Article
- Alterations in Circadian Rhythms, Sleep, and Physical Activity in COVID-19: Mechanisms, Interventions, and Lessons for the Future.Molecular neurobiology · 2024Review
- Physical activity status prevents symptoms of long covid: Sulcovid-19 survey.BMC sports science, medicine & rehabilitation · 2023Article
- A higher frequency of physical activity is associated with reduced rates of SARS-CoV-2 infection.The European journal of general practice · 2023Article
- Agility training to integratively promote neuromuscular, cardiorespiratory and cognitive function in healthy older adults: a one-year randomized-controlled trial.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2023Article
- Physical fitness level and the risk of severe COVID-19: A systematic review.Sports medicine and health science · 2023Review
- Exercise behavior, practice, injury, and symptoms of respiratory tract infection of 502 Brazilian adults during lockdown oscillations in two years (2021-2022) of the COVID-19 pandemic.BMC sports science, medicine & rehabilitation · 2023Article
- Baseline physical activity and the risk of severe illness and mortality from COVID-19: A dose-response meta-analysis.Preventive medicine reports · 2023Review
- Associations between Coronavirus and Immune Response, Cardiorespiratory Fitness Rehabilitation and Physical Activity: A Brief Report.International journal of environmental research and public health · 2023Article
- Role of epigenetics in the clinical evolution of COVID-19 disease. Epigenome-wide association study identifies markers of severe outcome.European journal of medical research · 2023Article
- Stress induced proinflammatory adaptations: Plausible mechanisms for the link between stress and cardiovascular disease.Frontiers in physiology · 2023Review
- Inflammation in COVID-19 and the Effects of Non-Pharmacological Interventions during the Pandemic: A Review.International journal of molecular sciences · 2022Review
- Cardiovascular health behavior and cardiorespiratory fitness in adolescents: a longitudinal study.European journal of pediatrics · 2022Article
- Association of food habit with the COVID-19 severity and hospitalization: A cross-sectional study among the recovered individuals in Bangladesh.Nutrition and health · 2022Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in China in late 2019 and has since spread rapidly to every continent in the world. This pandemic continues to cause widespread personal suffering, along with severe pressure on medical and health care providers. The symptoms of SARS-CoV-2 and the subsequent prognosis are worsened in individuals who have preexisting comorbidities prior to infection by the virus. Individuals with obesity or overweight, insulin resistance, and diabetes typically have chronic low-grade inflammation characterized by increased levels of several proinflammatory cytokines and the inflammasome; this state predisposes to greater risk for infection along with more adverse outcomes. Here, we consider whether a high level of cardiorespiratory fitness induced by prior exercise training may confer some innate immune protection against COVID-19 by attenuating the "cytokine storm syndrome" often experienced by "at risk" individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.