ArticleAngewandte Chemie (International ed. in English)2020
Nickela-electrocatalyzed Mild C-H Alkylations at Room Temperature.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Recent Advancements in Nickel-Catalyzed Electrochemical Reductive Cross-Coupling.ACS organic & inorganic Au · 2025Review
- Nickelaelectro-Catalyzed C─H Activation to β-Arylated Pyrroles via Multiple Dehydrogenation.Angewandte Chemie (International ed. in English) · 2025Article
- Isochromene and Dihydroisobenzofuran Electrosynthesis by a Highly Regiodivergent Cyclization of 2-Ethynylbenzaldehydes.The Journal of organic chemistry · 2025Article
- Nickel catalyzed multicomponent stereodivergent synthesis of olefins enabled by electrochemistry, photocatalysis and photo-electrochemistry.Nature communications · 2022Article
- Distal Ruthenaelectro-Catalyzed meta-C-H Bromination with Aqueous HBr.Angewandte Chemie (International ed. in English) · 2022Article
- Recent Advances in C(spACS organic & inorganic Au · 2022Review
- Alkylation of Nitropyridines via Vicarious Nucleophilic Substitution.Organic letters · 2022Article
- Electrochemical C-N bond activation for deaminative reductive coupling of Katritzky salts.Nature communications · 2021Article
- Redox-Neutral Cross-Coupling Amination with WeakJACS Au · 2021Article
- Electrocatalysis as an enabling technology for organic synthesis.Chemical Society reviews · 2021Article
- A facile method for Rh-catalyzed decarbonylativeRSC advances · 2021Article
- Organic Electrochemistry: Molecular Syntheses with Potential.ACS central science · 2021Review
- Electrooxidative Rhodium-Catalyzed [5+2] Annulations via C-H/O-H Activations.Angewandte Chemie (International ed. in English) · 2021Article
- Nickela-electrocatalyzed Mild C-H Alkylations at Room Temperature.Angewandte Chemie (International ed. in English) · 2020Article
- Renewable resources for sustainable metallaelectro-catalysed C-H activation.Chemical science · 2020Review
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3 authors.
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Abstract
Direct alkylations of carboxylic acid derivatives are challenging and particularly nickel catalysis commonly requires high reaction temperatures and strong bases, translating into limited substrate scope. Herein, nickel-catalyzed C-H alkylations of unactivated 8-aminoquinoline amides have been realized under exceedingly mild conditions, namely at room temperature, with a mild base and a user-friendly electrochemical setup. This electrocatalyzed C-H alkylation displays high functional group tolerance and is applicable to both the primary and secondary alkylation. Based on detailed mechanistic studies, a nickel(II/III/I) catalytic manifold has been proposed.
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