Evidence map›Paper›PMID 32324935›Full record

ArticleSynapse (New York, N.Y.)2020

Inverse changes in raphe and cortical 5-HT

Stephen R Baldassarri, Eunkyung Park, Sjoerd J Finnema, Beata Planeta, Nabeel Nabulsi, Soheila Najafzadeh, Jim Ropchan, Yiyun Huang, Jonas Hannestad, Kathleen Maloney and 2 more

Open access · greenAbstract read
In one paragraph

Article in Synapse (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  10. Integrating brainstem and cortical functional architectures.bioRxiv : the preprint server for biology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Stephen R BaldassarriSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-5928-3733
Eunkyung ParkDepartment of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, CT, USA.
Sjoerd J FinnemaDepartment of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, CT, USA.
Beata PlanetaDepartment of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, CT, USA.
Nabeel NabulsiDepartment of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, CT, USA.
Soheila NajafzadehDepartment of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, CT, USA.
Jim RopchanDepartment of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, CT, USA.
Yiyun HuangDepartment of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, CT, USA.
Jonas HannestadDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Kathleen MaloneyDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Zubin BhagwagarDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, CT, USA.
Yale University · USUniversity of Iowa Hospitals and Clinics · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Understanding Factors that Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine ReceptorsK23DA045957 · NIDA · YALE UNIVERSITY · PI BALDASSARRI, STEPHEN · 2018 to 2022
$983k
A study of GABA and 5-HT interactions to test a molecular model of vulnerabilityK23MH077914 · NIMH · YALE UNIVERSITY · PI BHAGWAGAR, ZUBIN · 2007 to 2009
$543k
NCATS NIH HHS UL1 TR001863NIDA NIH HHS K23 DA045957NIMH NIH HHS K23 MH077914
6 · The paper itself

Abstract

Serotonergic neurotransmission plays a key role in the pathophysiology and treatment of various neuropsychiatric diseases. The purpose of this study was to investigate changes in serotonergic neurotransmission after acute tryptophan depletion (ATD) using positron emission tomography (PET) with [

Indexed as

AdultCerebral CortexFemaleHumansMaleMiddle AgedPiperazinesPositron-Emission TomographyProtein BindingPyrrolidinonesRadiopharmaceuticalsRaphe NucleiReceptor, Serotonin, 5-HT1BSerotonin 5-HT1 Receptor AntagonistsTryptophan1-(4-(2-methoxyisopropyl)phenyl)-3-(2-(4-methylpiperazin-1-yl)benzyl)pyrrolidin-2-onePiperazinesPyrrolidinonesRadiopharmaceuticalsReceptor, Serotonin, 5-HT1BSerotonin 5-HT1 Receptor AntagonistsTryptophan[11C]P9435-HT1B receptoracute tryptophan depletionbinding potentialpositron emission tomographyserotonin

Identifiers

PMID32324935
PMCPMC7426238
OpenAlexW3018152393

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.