ArticleJournal of pediatric psychology2020
Sex Differences in Early Cognitive Development After Prenatal Exposure to Opioids.
Article in Journal of pediatric psychology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Adolescent prefrontal and amygdala molecular signatures of perinatal morphine versus buprenorphine exposure in mice.Neurotoxicology · 2026Article
- Neurodevelopmental challenges at age four following fetal exposure to maternal opioid maintenance treatment.Pediatric research · 2025Article
- Prefrontal cortical microglial transcriptome relates to mouse offspring executive function deficits after perinatal opioid exposure in a sex-dependent manner.Brain, behavior, and immunity · 2025Article
- Maternal exposure to buprenorphine, but not methadone, during pregnancy reduces social play behavior across two generations of offspring.Psychopharmacology · 2025Article
- Early developmental trajectory of children with prenatal alcohol and opioid exposure.Pediatric research · 2024Article
- Sex-specific alterations in cognitive control following moderate prenatal alcohol exposure and transient systemic hypoxia ischemia in the rat.Alcohol, clinical & experimental research · 2024Article
- Sex differences in neonatal outcomes following prenatal opioid exposure.Frontiers in pediatrics · 2024Review
- Parental substance use and home visiting programs: Implementation considerations for relationship-based treatment.Infant mental health journal · 2023Article
- Early emotional caregiving environment and associations with memory performance and hippocampal volume in adolescents with prenatal drug exposure.Frontiers in behavioral neuroscience · 2023Article
- Prenatal exposure to opioids and neurodevelopment in infancy and childhood: A systematic review.Frontiers in pediatrics · 2023Review
- Preschool Language Development of Children Born to Women with an Opioid Use Disorder.Children (Basel, Switzerland) · 2021Article
- JPP Student Journal Club Commentary: Opioid Exposure and Cognitive Development: Unpacking Clinical Relevance.Journal of pediatric psychology · 2020Article
- Co-occurrence of preconception maternal childhood adversity and opioid use during pregnancy: Implications for offspring brain development.Neurotoxicology and teratologyArticle
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrenatal opioid exposure has been linked with impaired cognitive development, with boys potentially at elevated risk. In the present study, we examined cognitive and language development of children prenatally exposed to opioids, with an additional focus on sex differences.
methodsA sample of 378 children (n = 194 girls and n = 184 boys) aged 1.2-42.8 months was drawn from the Danish Family Outpatient Clinic database. Developmental outcomes were assessed using the Bayley-III cognitive and language scales, and substance exposure was determined with urine screening and/or verbal report. Children exposed to opioids (n = 94) were compared to children with no prenatal substance exposure (n = 38), and children exposed to alcohol (n = 131) or tobacco (n = 115). Group and sex differences were investigated with separate linear mixed models for each Bayley scale, controlling for concurrent cannabis exposure.
resultsThere were significantly reduced scores in opioid-exposed boys compared to boys with no prenatal substance exposure, but no difference between opioid-exposed and nonexposed girls. Additionally, alcohol-exposed boys had lower cognitive scores than nonexposed boys, and alcohol-exposed girls had lower scores on both scales compared to opioid-exposed girls. There were otherwise no significant differences according to group, sex, or scale.
conclusionsThe present findings indicate poorer cognitive and language development in boys after prenatal opioid exposure. As academic performance is rooted in cognitive functioning, long-term follow-up might be necessary for exposed children.
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