Evidence map›Paper›PMID 32324809›Full record

ArticlePloS one2020

Prevalence of iron deficiency in 62,685 women of seven race/ethnicity groups: The HEIRS Study.

James C Barton, Howard H Wiener, Ronald T Acton, Paul C Adams, John H Eckfeldt, Victor R Gordeuk, Emily L Harris, Christine E McLaren, Helen Harrison, Gordon D McLaren and 1 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 42 citations in OpenAlex.

  1. Cortisol Stress Response is Associated with Iron Status in Pregnancy.medRxiv : the preprint server for health sciences · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Prevalence of Risk of Iron Deficiency.Canadian journal of pain = Revue canadienne de la douleur · 2026
    Article
  6. Article
  7. Article
  8. Correlation of sleep-disordered breathing with anemia and microcytosis in premenopausal females: the Nagahama study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
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  14. Article
  15. Review
  16. Article
  17. Iron Deficiency in Korean Patients With Heart Failure.Journal of Korean medical science · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

James C BartonDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA and Southern Iron Disorders Center, Birmingham, AL, United States of America.ORCID 0000-0003-2876-8276
Howard H WienerDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Ronald T ActonUSA and Southern Iron Disorders Center, Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Paul C AdamsDepartment of Medicine, London Health Sciences Centre, London, ONT, Canada.
John H EckfeldtDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States of America.
Victor R GordeukDivision of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States of America.
Emily L HarrisDivision of Cancer Control and Population Sciences, Epidemiology and Genomics Research Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States of America.
Christine E McLarenDepartment of Epidemiology, University of California, Irvine, CA, United States of America.
Helen HarrisonThe Western-Fanshawe Collaborative BScN Program, Fanshawe College, London, ONT, Canada.ORCID 0000-0001-8660-7118
Gordon D McLarenDivision of Hematology/Oncology, Department of Medicine, University of California, Irvine, CA, USA and Department of Veterans Affairs Long Beach Healthcare System, Long Beach, CA, United States of America.
David M ReboussinDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.
University of Alabama at Birmingham · USUniversity of California, Irvine · USFanshawe College · CALondon Health Sciences Centre · CANational Institutes of Health · USUniversity of Illinois Chicago · USUniversity of Minnesota · USWake Forest University · US

Funding

Zevalin Radioimmunotherapy Using a Modified TreatmentM01RR000032 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RICH, ROBERT R. · 1985 to 2008
$23.6M
IRON OVERLOAD AND HEREDITARY HEMOCHROMATOSISN01HC005185 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ECKFELDT, JOHN H · 2000 to 2000
$1.1M
IRON OVERLOAD AND HEREDITARY HEMOCHROMATOSIS-N01HC5192-268005192-268005192N01HC005192 · HC · WAKE FOREST UNIVERSITY · PI REBOUSSIN, DAVID M · 2000 to 2006
$867k
IRON OVERLOAD AND HEREDITARY HEMOCHROMOTOSISN01HC005189 · HC · KAISER FOUNDATION RESEARCH INSTITUTE · PI HARRIS, EMILY L · 2000 to 2000
$500k
IRON OVERLOAD AND HEREDITARY HEMOCHROMATOSIS STUDYN01HC005190 · HC · UNIVERSITY OF CALIFORNIA IRVINE · PI MCLAREN, CHRISTINE E · 2000 to 2000
$338k
IRON OVERLOAD AND HEREDITARY HEMOCHROMOTOSIS STUDYN01HC005188 · HC · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ACTON, RONALD T. · 2000 to 2000
$256k
IRON OVERLOAD AND HEREDITARY HEMOCHROMATOSISN01HC005186 · HC · HOWARD UNIVERSITY · PI GORDEUK, VICTOR R · 2000 to 2000
$223k
IRON OVERLOAD AND HEREDITARY HEMOCHROMATOSIS STUDY-FIELDN01HC005191 · HC · LONDON HEALTH SCIENCES CENTER · PI ADAMS, PAUL · 2000 to 2000
$218k
NCI NIH HHS N01 CM007003NCRR NIH HHS M01 RR000032NHLBI NIH HHS N01 HC005185NHLBI NIH HHS N01 HC005186NHLBI NIH HHS N01 HC005188NHLBI NIH HHS N01 HC005189NHLBI NIH HHS N01 HC005190NHLBI NIH HHS N01 HC005191NHLBI NIH HHS N01 HC005192
6 · The paper itself

Abstract

backgroundFew cross-sectional studies report iron deficiency (ID) prevalence in women of different race/ethnicity and ages in US or Canada. MATERIALS AND

methodsWe evaluated screening observations on women who participated between 2001-2003 in a cross-sectional, primary care-based sample of adults ages ≥25 y whose observations were complete: race/ethnicity; age; transferrin saturation; serum ferritin; and HFE p.C282Y and p.H63D alleles. We defined ID using a stringent criterion: combined transferrin saturation <10% and serum ferritin <33.7 pmol/L (<15 μg/L). We compared ID prevalence in women of different race/ethnicity subgrouped by age and determined associations of p.C282Y and p.H63D to ID overall, and to ID in women ages 25-44 y with or without self-reported pregnancy.

resultsThese 62,685 women included 27,079 whites, 17,272 blacks, 8,566 Hispanics, 7,615 Asians, 449 Pacific Islanders, 441 Native Americans, and 1,263 participants of other race/ethnicity. Proportions of women with ID were higher in Hispanics and blacks than whites and Asians. Prevalence of ID was significantly greater in women ages 25-54 y of all race/ethnicity groups than women ages ≥55 y of corresponding race/ethnicity. In women ages ≥55 y, ID prevalence did not differ significantly across race/ethnicity. p.C282Y and p.H63D prevalence did not differ significantly in women with or without ID, regardless of race/ethnicity, age subgroup, or pregnancy.

conclusionsID prevalence was greater in Hispanic and black than white and Asian women ages 25-54 y. p.C282Y and p.H63D prevalence did not differ significantly in women with or without ID, regardless of race/ethnicity, age subgroup, or pregnancy.

Indexed as

AdultAgedAnemia, Iron-DeficiencyCanadaCross-Sectional StudiesEthnicityFemaleFerritinsHemochromatosis ProteinHumansMiddle AgedMutationPrevalenceTransferrinUnited StatesFerritinsHemochromatosis ProteinHFE protein, humanTransferrin

Identifiers

PMID32324809
PMCPMC7179917
OpenAlexW3019542915

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.