ArticlePloS one2020
Declines in grip strength may indicate early changes in cognition in healthy middle-aged adults.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A qualitative systematic review of individual differences in Stroop task performance among healthy adults.Psychological research · 2026Pooled it
- The association of multi-system health status and its longitudinal changes with cardiovascular disease risk: insights from a secondary analysis of four multinational cohort studies.Journal of global health · 2026Article
- Hand Grip Strength Predicts Cognitive Decline in Subjective Cognitive Decline: 2-Year Follow-up Results.Journal of Korean medical science · 2026Article
- Physical fitness and incident mild cognitive impairment: a systematic review.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Review
- Multi-domain predictors of grip strength differentiate individuals with and without alcohol use disorder.Addiction biology · 2024Article
- Article
- Grip strength and depressive symptoms in Chinese middle-aged and older adults: the mediating effects of cognitive function.Frontiers in aging neuroscience · 2024Article
- Sex-modified association between grip strength and mild cognitive impairment: a cross-sectional and follow-up study in rural China.BMC geriatrics · 2023Article
- Clinical Significance of Physical Frailty in Subjects With Subjective Cognitive Decline: A Prospective Study With Amyloid PET Data.Journal of clinical neurology (Seoul, Korea) · 2023Article
- How we get a grip: Microstructural neural correlates of manual grip strength in children.NeuroImage · 2023Article
- Thigh and Calf Myosteatosis are Strongly Associated with Muscle and Physical Function in African Caribbean Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Longitudinal grip strength is associated with susceptibility to the Sound Induced Flash Illusion in older adults.Aging brain · 2023Article
- The relationship between clinical measures of cognitive function and grip strength in healthy older adults.BMC geriatrics · 2022Article
- Simultaneous monitoring of mouse grip strength, force profile, and cumulative force profile distinguishes muscle physiology following surgical, pharmacologic and diet interventions.Scientific reports · 2022Article
- Associations of low handgrip strength and hand laterality with cognitive function and functional mobility - the Yishun Study.BMC geriatrics · 2022Article
- Grip Strength Trajectories and Cognition in English and Chilean Older Adults: A Cross-Cohort Study.Journal of personalized medicine · 2022Article
- A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls.Healthcare (Basel, Switzerland) · 2022Article
- Muscular Function as an Alternative to Identify Cognitive Impairment: A Secondary Analysis From SABE Colombia.Frontiers in neurology · 2022Article
- Income-Related Mortality Inequalities and Its Social Factors among Middle-Aged and Older Adults at the District Level in Aging Seoul: An Ecological Study Using Administrative Big Data.International journal of environmental research and public health · 2021Article
- Association between change in handgrip strength and cognitive function in Korean adults: a longitudinal panel study.BMC geriatrics · 2021Article
Corrections and comments
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Declining grip strength is an indicator of cognitive loss in older individuals but it has not been explored people younger than 65 years old. The purpose of this study was to investigate the relationship between grip strength and specific cognitive tests known to decline with mild cognitive impairment in young and middle-aged adults. Declines in cognitive performance in middle-aged adults may provide evidence that these changes occur earlier than previously reported. A cross sectional design was used to compare differences between young and middle-aged healthy adults and to investigate associations between cognitive and grip strength measures within groups. Healthy young (20-30 years old) and middle-aged (45-65 years old) adults completed five cognitive tests including the Stroop, California Verbal Learning Test, Symbol Digit Modalities Test, Trail Making Tests and the Controlled Oral Word Association Test. All participants completed right and left maximum grip strength measures. Middle-aged adults performed significantly worse on right and left grip strength and the Stroop test (p<0.05) when compared to the younger group. There were no significant relationships among grip strength and cognitive performance at the whole-group level or within the younger-age group; however, weaker grip strength was significantly associated with poorer Controlled Oral Word Association Test total cluster (r = 0.458; p < .05) and Stroop interference (r = 0.471; p < .05) scores in the middle-aged group. Findings from this study suggest that cognitive changes may occur earlier than previously thought (prior to age 65). Weaker grip strength was significantly associated with poorer function in two of the cognitive measures in the middle-age group, suggesting that some domains of cognition, specifically semantic categorization and executive function, may be particularly sensitive to age-related changes.
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