ArticlePLoS neglected tropical diseases2020
Study of Usutu virus neuropathogenicity in mice and human cellular models.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 40 citations in OpenAlex.
- Differential properties of NS1 glycoproteins in West Nile and Usutu viruses.Emerging microbes & infections · 2026Article
- A versatile fluorescent reporter for Usutu virus drug screening and infection tracking.PNAS nexus · 2026Article
- Neuropathogenesis of Usutu virus-associated disease in Eurasian blackbirds (Turdus merula) involves apoptosis through the extrinsic pathway.Journal of neurovirology · 2026Article
- First report of Usutu virus fatal infections in Chilean tinamous (Nothoprocta perdicaria), brahminy starlings (Sturnia pagodarum), and multiple other bird species in zoological gardens and wildlife in the Czech Republic.One health outlook · 2026Article
- Extrapolation and comparison of West Nile virus- and Usutu virus-associated neurological diseases in humans: linking pathology to clinical symptoms.Clinical microbiology reviews · 2025Review
- First documented case of a fatal autochthonous Usutu virus infection in an immunocompromised patient in Hungary: a clinical-virological report and implications from the literature.Virology journal · 2025Article
- Cross-protection against St. Louis encephalitis virus and Usutu virus by West Nile virus convalescent plasma.Virology · 2025Article
- STAT1-mediated interferon signaling in the hematopoietic system is essential for restricting Usutu virus infection in vivo.PLoS neglected tropical diseases · 2025Article
- A central role for CCR2 in monocyte recruitment and blood-brain barrier disruption during Usutu virus encephalitis.Journal of neuroinflammation · 2025Article
- MITD1 is a brain-specific interferon-inducible factor that inhibits flavivirus replication.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Usutu virus-induced meningoencephalitis in immunocompetent mice is characterized by the recruitment of mononuclear cells and a proinflammatory T helper 1 response.Journal of virology · 2025Article
- Dose and strain dependent lethality of Usutu virus in an IfnarNpj viruses · 2025Article
- Emerging mosquito-borne flaviviruses.mBio · 2024Review
- Usutu virus and West Nile virus use a transcellular route of neuroinvasion across an in vitro model of the human blood-brain barrier.Npj viruses · 2024Article
- Review
- Skin tropism during Usutu virus and West Nile virus infection: an amplifying and immunological role.Journal of virology · 2024Article
- Article
- Epidemiology, surveillance and diagnosis of Usutu virus infection in the EU/EEA, 2012 to 2021.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023Review
- [French research organization on emerging infectious diseases: From REACTing to ANRS emerging infectious diseases].Bulletin de l'Academie nationale de medecine · 2023Review
- Competition between two Usutu virus isolates in cell culture and in the common house mosquitoFrontiers in microbiology · 2023Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Usutu virus (USUV), an African mosquito-borne flavivirus closely related to West Nile virus, was first isolated in South Africa in 1959. USUV emerged in Europe two decades ago, causing notably massive mortality in Eurasian blackbirds. USUV is attracting increasing attention due to its potential for emergence and its rapid spread in Europe in recent years. Although mainly asymptomatic or responsible for mild clinical signs, USUV was recently described as being associated with neurological disorders in humans such as encephalitis and meningoencephalitis, highlighting the potential health threat posed by the virus. Despite this, USUV pathogenesis remains largely unexplored. The aim of this study was to evaluate USUV neuropathogenicity using in vivo and in vitro approaches. Our results indicate that USUV efficiently replicates in the murine central nervous system. Replication in the spinal cord and brain is associated with recruitment of inflammatory cells and the release of inflammatory molecules as well as induction of antiviral-responses without major modulation of blood-brain barrier integrity. Endothelial cells integrity is also maintained in a human model of the blood-brain barrier despite USUV replication and release of pro-inflammatory cytokines. Furthermore, USUV-inoculated mice developed major ocular defects associated with inflammation. Moreover, USUV efficiently replicates in human retinal pigment epithelium. Our results will help to better characterize the physiopathology related to USUV infection in order to anticipate the potential threat of USUV emergence.
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