Evidence map›Paper›PMID 32324447›Full record

ArticleJCO clinical cancer informatics2020

Open Health Imaging Foundation Viewer: An Extensible Open-Source Framework for Building Web-Based Imaging Applications to Support Cancer Research.

Erik Ziegler, Trinity Urban, Danny Brown, James Petts, Steve D Pieper, Rob Lewis, Chris Hafey, Gordon J Harris

Abstract read
In one paragraph

Article in JCO clinical cancer informatics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
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  6. Report on the 2025 DICOM WSI Connectathon.Journal of pathology informatics · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. A Framework for Cross-Domain Generalization in Coronary Artery Calcium Scoring Across Gated and Non-Gated Computed Tomography.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Web-Based DICOM Viewers: A Survey and a Performance Classification.Journal of imaging informatics in medicine · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Erik ZieglerOpen Health Imaging Foundation, Boston, MA.
Trinity UrbanOpen Health Imaging Foundation, Boston, MA.
Danny BrownOpen Health Imaging Foundation, Boston, MA.
James PettsOpen Health Imaging Foundation, Boston, MA.
Steve D PieperOpen Health Imaging Foundation, Boston, MA.
Rob LewisOpen Health Imaging Foundation, Boston, MA.
Chris HafeyOpen Health Imaging Foundation, Boston, MA.
Gordon J HarrisOpen Health Imaging Foundation, Boston, MA.

Funding

Lymph Node Quantification System for Multisite Clinical TrialsR01CA235589 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GORDON J HARRIS, Ron Kikinis · 2019 to 2026
$4.5M
Extensible open-source zero-footprint web viewer for oncologic imaging researchU24CA199460 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI HARRIS, GORDON J · 2015 to 2019
$3.5M
Extensible Open Source Zero-Footprint Web Viewer for Cancer Imaging ResearchU24CA258511 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI GORDON J HARRIS · 2023 to 2026
$3.3M
NCI NIH HHS R01 CA235589NCI NIH HHS U24 CA199460NCI NIH HHS U24 CA258511
6 · The paper itself

Abstract

purposeZero-footprint Web architecture enables imaging applications to be deployed on premise or in the cloud without requiring installation of custom software on the user's computer. Benefits include decreased costs and information technology support requirements, as well as improved accessibility across sites. The Open Health Imaging Foundation (OHIF) Viewer is an extensible platform developed to leverage these benefits and address the demand for open-source Web-based imaging applications. The platform can be modified to support site-specific workflows and accommodate evolving research requirements. MATERIALS AND

methodsThe OHIF Viewer provides basic image review functionality (eg, image manipulation and measurement) as well as advanced visualization (eg, multiplanar reformatting). It is written as a client-only, single-page Web application that can easily be embedded into third-party applications or hosted as a standalone Web site. The platform provides extension points for software developers to include custom tools and adapt the system for their workflows. It is standards compliant and relies on DICOMweb for data exchange and OpenID Connect for authentication, but it can be configured to use any data source or authentication flow. Additionally, the user interface components are provided in a standalone component library so that developers can create custom extensions.

resultsThe OHIF Viewer and its underlying components have been widely adopted and integrated into multiple clinical research platforms (e,g Precision Imaging Metrics, XNAT, LabCAS, ISB-CGC) and commercial applications (eg, Osirix). It has also been used to build custom imaging applications (eg, ProstateCancer.ai, Crowds Cure Cancer [presented as a case study]).

conclusionThe OHIF Viewer provides a flexible framework for building applications to support imaging research. Its adoption could reduce redundancies in software development for National Cancer Institute-funded projects, including Informatics Technology for Cancer Research and the Quantitative Imaging Network.

Indexed as

NeoplasmsUser-Computer InterfaceDiagnostic ImagingHumansInformation Storage and RetrievalInternetSoftware

Identifiers

PMID32324447
PMCPMC7259879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.